4－硝基邻苯二甲酸根桥联双核钴（Ⅱ）配合物的合成、磁性及抗癌活性  

Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes

作　　者：石敬民[1] 廖代正[1] 程鹏[1] 缪明明[1] 姜宗慧[1] 刘永江[1] 王耕霖[1] 

机构地区：[1]南开大学化学系

出　　处：《应用化学》1996年第4期86-88,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金;配位化学国家重点实验室资助

摘　　要：４－硝基邻苯二甲酸根桥联双核钴（Ⅱ）配合物的合成、磁性及抗癌活性石敬民，廖代正，程鹏，缪明明，姜宗慧，刘永江，王耕霖（南开大学化学系天津３０００７１）关键词硝基邻苯二甲酸根，双核钴（Ⅱ）配合物，磁性，生物活性研究桥联多核配合物的磁性不仅有助于了解桥联...Two new novel binuclear cobalt (Ⅱ) complexes, namely,[Co_2 (4PT) (Phen)_4]( ClO_4 )_2· 3H_2O (complex 1) and[Co_2 (4PT)(NPhen)_4] (ClO_4)_2·2H_2O (complex 2) (4PT=4-nitrophthalato , Phen=l,10-phenanthroline , NPhen = 5-nitro-1,10-phenanthroline) have been synthesized. The complexes were characterized by elemental analysis, IR, UV-Vis spectra and electronic conductance. The variable-temperature magnetic susceptibility of the complexes was measured over 77￣300 K. The data were analyzed by using the magnetic susceptibility equation based on Heisenberg spin-exchange operator, and the exchange integrals for complex 1 and complex 2 were found 2J= - 8. 6 cm￣(-1) and 2J=-4. 3 cm￣(-1),respectively. Experiments of inhibiting human leukemia cell, stomach cancer cell and carcinoma of nasopharyngeal cancer cell in vitro were made,and found that the complexes exhibited a relatively strong function of inhibiting these three kinds of cancer cells.

关 键 词：硝基 邻苯二甲酸 配合物 磁性 钴 抗癌活性 

分 类 号：O614.812[理学—无机化学] R979.1[理学—化学]