放疗联合复方苦参注射液治疗食管癌临床分析  

Clinical analys of esophageal cancer patients treated by combined composite Kushen injection and radiotherapy

作　　者：蔡平[1] 刘庆深[1] 陈画华[1] 李忆璇[1] 李惜辉[1] 

机构地区：[1]广东省汕头市中心医院放疗科,515031

出　　处：《肿瘤研究与临床》2006年第6期395-396,399,共3页Cancer Research and Clinic

摘　　要：目的探讨放疗中联合应用复方苦参注射液治疗食管癌的疗效及减少放疗的毒副作用情况。方法对126例初次入院食管癌放疗患者进行回顾性分析,一组行单纯超分割放疗(单放组),总剂量DT66￣74Gy/6￣7周,2.2～2.4Gy/d。另一组在超分割放疗的同时加用复方苦参注射液(综合组)20ml加入生理盐水500ml静脉滴注,1次/d,连用20d。结果放疗结束时食管X线造影片分级,综合治疗组Ⅰ级片占60.4%,明显高于单放组的41%(χ2=4.57,P<0.05);综合组1年生存率为73.6%,明显高于单放组的54.8%(χ2=4.63,P<0.05);单放组放射性食管炎及放射性气管炎发生率明显高于综合组(P<0.05,P<0.01)。结论食管癌放疗的同时加用复方苦参注射液,具有增敏和降低放疗毒副反应的作用。Objective To analyze the efficacy and debase the toxicity of radiotherapy combined with composite Kushen injection in treatment of esophageal carcinoma patients. Methods A total of 126 cases of esophageal cancer were treated by radiotherapy were analysed. All patients were treated with the continuative hyperfractionated radiotherapy. The total dose was 66～74 Gy/5～7 wk, 2.2～2.4 Gy/d of esophageal carcinoma patients. Two groups were given respectively delivered with the same radioactive dosages and methods. But the synthetic group was treated by radiotherapy with composite Kushen injection, composite Kushen injection was given at the dosage of 20 ml with 500 ml of saline infusion for 20 consecutive days. Results X-ray grades of esophageal cancer after radiotherapy. The grade Ⅰ of X-ray manifestation after radiotherapy for patients in synthetic group was superior to that patient in the radiotherapy alone group. （60.4 % vs 41%; X^2 = 4.57, P 〈 0.05）, The 1-year survival was much higher in synthetic group patients than radiotherapy alone group ones （73.6 % vs 54.8 %, X^2 = 4.63; P 〈 0.05）. Radiation-esophagitis, radiation-bronchitis was much higher in radiotherapy alone group patients than synthetic group ones （P 〈 0.05, P 〈 0.01）. Conclusions Composite Kushen injection can improve curative effect of radiotherapy of esophageal cancer and significantly decreased side effect of radiotherapy.

关 键 词：食管癌 复方苦参注射液 放疗毒副作用 

分 类 号：R735.1[医药卫生—肿瘤]