多发性骨髓瘤细胞遗传学异常研究进展  

Advancement in cytogenetics of multiple myeloma

作　　者：邓书会[1] 邱录贵[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所血液病医院血液五科,天津300020

出　　处：《白血病．淋巴瘤》2006年第3期226-228,共3页Journal of Leukemia & Lymphoma

摘　　要：随着细胞遗传学和分子生物学技术的迅速发展,人们对多发性骨髓瘤(MM)中细胞遗传学异常的认识逐渐加深。MM细胞遗传学异常以非整倍体核型、13号染色体异常、Ig易位等为主,具有独特的分子生物学改变,与疾病的临床特点密切相关。对此领域进行深入探讨,将有助于我们了解MM的发生、发展机制,建立更合理有效的诊治策略。With the advent of new cytogenetical and molecular techniques ,our knowledge of the cytogenetics in multiple myeloma（MM） becomes more and more clear. The main cytogenetic abnormalities are aneuploidy,chromosome 13 abnormality and translocations involving immunoglobulin locus. All the aberrations result in unique changes of molecular biology and have intense clinical implications. More effort in this territory will offer us better understanding of MM＇s pathogenesis and form the platform for curative therapy.

关 键 词：多发性骨髓瘤 细胞遗传学异常 

分 类 号：R733.3[医药卫生—肿瘤]