乙二胺桥联环糊精二聚体的多重识别研究  

Study on the Multiple Recognition of β - Cyclodextrin Dimer Bridged with Two 1,2- Diamioethane

作　　者：宋乐新[1] 孟庆金[2] 游效曾[2] 

机构地区：[1]苏州大学化学系,苏州215006 [2]南京大学配位化学研究所,南京210093

出　　处：《化学学报》1996年第8期777-782,共6页Acta Chimica Sinica

基　　金：国家科委重大基础研究项目;国家和江苏省自然科学基金资助

摘　　要：本文合成了由两个乙二胺分子桥联的β-环糊精二聚体(1).在碱性溶液中1与二价铜离子形成稳定的配合物(2),根据客体分子被包合前后主、客体质子化学位移的变化研究了水溶液中三个主体分子:β-环糊精、1和2分别与对、间和邻氯苯酚及其钠盐的包合反应.通过比较主-客体包合物生成常数的大小可以推断2与有机阴离子客体之间存在多重识别作用.The β - cyclodextrin dimer (1, host) bridged two 1,2- diaminoethane was synthesized by using a regiospecific capping reagent(m - benzenedisulfonyl chloride). The research we have done indicated that the dimer and Cu2+ ion formed a stable coordination compound(2, host) . The evidence that p-, m - or o - chlorophenol and p - , m - or o- chlorophenolate(guests) wasincluded by β- cyclodextrin, 1 and 2 respectively, comes from 1H NMR spectroscopic studiesperformed on the host - guest inclusion compounds in D2O at 22℃. Comparison of the formation constants of inclusion compounds revealed that there is a multiple recognition mechanism in existence between the host molecule(2) and the organic anion guest.

关 键 词：Β-环糊精 金属酶模型 修饰 多重识别 分子组装 

分 类 号：O636.12[理学—高分子化学]