T和NK细胞淋巴瘤152例病理学特点及类型构成分析  

Pathological features and types of T and NK cell lymphomas based on 152 cases

作　　者：张淑红[1] 周小鸽[1] 张彦宁[1] 王鹏[1] 张长淮[1] 黄受方[1] 

机构地区：[1]首都医科大学附属北京友谊医院病理科,北京100050

出　　处：《诊断病理学杂志》2006年第3期190-193,i0008,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的分析152例T和NK细胞淋巴瘤的病理学特点及类型构成情况.方法复查北京友谊医院1985-2005年经病理诊断为淋巴组织肿瘤的病例,按照WHO（2001）淋巴组织肿瘤分类标准,根据形态学、免疫组化、EB病毒原位杂交结合临床资料重新诊断分类,其中152例诊断为T和NK细胞淋巴瘤.结果152例患者平均年龄43岁（4～80岁）,男女之比约为3：1.淋巴结外83例（54.6%）,淋巴结内69例（45.4%）.本组152例共见到10种类型,其中最常见的类型是结外鼻型NK/T细胞淋巴瘤（52例,占34.2%）,其次为非特殊类型外周T细胞淋巴瘤（31例,占20.4%）、前驱T淋巴母细胞淋巴瘤（25例,占16.4%）、间变性大细胞淋巴瘤（21例,占13.8%）.结外鼻型NK/T细胞淋巴瘤的EB病毒阳性率为98%（51/52）.结论T和NK细胞淋巴瘤的形态学变化范围很大,但各类具有一定的病理学特点,是进一步分类的形态学基础;最常见的类型是结外鼻型NK/T细胞淋巴瘤;与欧美等地区相比较,国内T和NK细胞淋巴瘤的发病情况明显不同,提示可能存在不同的发病因素.Objective To study the pathological features of T and NK cell lymphomas and the relative frequency of each type of these lymphomas. Methods 152 cases of T and NK cell lymphomas selected from archival tissues of lymphoid neoplasms diagnosed during the period of 1985 - 2005 were studied based on morphology, immunohistochemistry and in situ hybridization for Epstein-Barr virus （EBER） and correlated clinical findings, and reclassified according to new WHO classification （2001）. Results The mean age of all the patients was 43 years old, ranged from 4 to 80 years old. The ratio of male to female was 3 to 1. There were 83 cases （54.6 % ） of extranodal lymphomas and 69 cases （ 45.4 % ） of nodal lymphomas. Ten types were identified in 152 cases of T and NK cell lymphoma. The most frequent type of the lymphoma was extmnodal nasal NK/T cell lymphoma （52 cases, 34.2% ）, followed by unspecified peripheral T cell lymphoma （31 cases, 20.4% ）, precursor T lymphoblastic lymphoma （25 cases, 16.4% ） and anaplastic large cell lymphoma （21 cases, 13.8% ）. Epstein-Ban- virus was detected in 51 of 52 eases （98 % ） of extralnodal nasal NK/T cell lymphoma. Conclusions T and NK cell lymphomas show great morphological diversity. And each type has certain pathological features, which are the base of further classification. The most common type is extranodal nasal NK/T cell lymphoma. Frequency of T and NK cell lymphomas showed in this study in China is different from that in European and American countries, suggesting there may be different etiological factors.

关 键 词：T细胞淋巴瘤 NK细胞淋巴瘤 临床病理 

分 类 号：R733.1[医药卫生—肿瘤]