埃索美拉唑与奥美拉唑治疗老年反流性食管炎疗效比较  被引量：9

COMPARATIVE EFFECTS OF ESOMEPRAZOLE AND OMEPRAZOLE IN TREATING REFLUX ESOPHAGITIS OF THE AGED</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=22178890' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('uFVWzIhOtVnkjH2XafGO2eYospmqXy1qrPyhntiGmcw=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="uFVWzIhOtVnkjH2XafGO2eYospmqXy1qrPyhntiGmcw="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" name="collRemark" id="collSumRemark" /> </p> <p style="text-align: center;"> <a href="javascript:void(0)" onclick="g_collectSumOk();"> <img width="65" height="17" src="/images_new/collect_ok.png" alt="完成" /></a> <a href="javascript:void(0)" onclick="g_collectSumCancel();"> <img width="65" height="17" src="/images_new/collect_no.png" alt="取消" /></a> </p> </div> </div> </div> <form name="wxTransfer" method="post"> <input type="hidden" name="lid" value="" /> <input type="hidden" name="sip" value="" /> <input type="hidden" name="date" value="" /> <input type="hidden" name="co" value="" /> <input type="hidden" name="Title_C" value="" /> <input type="hidden" name="Writers" value="" /> <input type="hidden" name="Name_C" value="" /> <input type="hidden" name="Num" value="" /> <input type="hidden" name="Years" value="" /> <input type="hidden" name="Volumn" value="" /> <input type="hidden" name="GCH" value="" /> <input type="hidden" name="Vol" value="" /> <input type="hidden" name="BookID" value="" /> <input type="hidden" name="SubjectNum" value="" /> <input type="hidden" name="SpecialNum" value="" /> <input type="hidden" name="mirrorName" value="" /> <input type="hidden" name="UserID" value="" /> <input type="hidden" name="UserName" value="" /> <input type="hidden" name="sourceID" value="" /> </form> <script type="text/javascript" src="/scripts/transfer.min.js"></script> <div class="article-detail"> <p class='author'><strong>作　　者：</strong><a href='/writer/article.aspx?id=100000020060426' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%bc%a0%e9%a2%96%5d' title='张颖[1]'>张颖[1]</a> <a href='/writer/article.aspx?id=100000013526146' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%b5%b5%e5%b0%9a%e6%95%8f%5d' title='赵尚敏[1]'>赵尚敏[1]</a> <a href='/writer/article.aspx?id=100000002206559' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%9d%a8%e6%a0%91%e5%b9%b3%5d' title='杨树平[2]'>杨树平[2]</a> <a href='/writer/article.aspx?id=100000012506436' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e4%ba%8e%e6%99%93%e5%b3%b0%5d' title='于晓峰[1]'>于晓峰[1]</a> <a href='/writer/article.aspx?id=100000005511119' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%a4%8f%e4%bf%8a%5d' title='夏俊[1]'>夏俊[1]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=517&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%8d%8e%e4%b8%9c%e5%8c%bb%e9%99%a2%e6%b6%88%e5%8c%96%e7%a7%91' title='[1]华东医院消化科,上海市200040'>[1]华东医院消化科,上海市200040</a> <a href='/organ/article.aspx?id=517&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%8d%8e%e4%b8%9c%e5%8c%bb%e9%99%a2%e8%80%81%e5%b9%b4%e7%a7%91' title='[2]华东医院老年科,上海市200040'>[2]华东医院老年科,上海市200040</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=81670X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e8%80%81%e5%b9%b4%e5%8c%bb%e5%ad%a6%e4%b8%8e%e4%bf%9d%e5%81%a5%5d' title='老年医学与保健'>《老年医学与保健》</a>2006年第2期89-92,共4页<em>Geriatrics & Health Care</em></p><p class='abstrack'><strong>摘　　要：</strong>目的观察比较埃索美拉唑与奥美拉唑缓解老年人反流性食管炎的反流性症状、食管炎愈合的疗效及其安全性。方法80例经内镜证实的反流性食管炎患者,平均年龄74.26±6.64岁,随机分为两组,分别给予口服埃索美拉唑与奥美拉唑20mg,每日2次。治疗4周和8周时分别观察临床症状、内镜下食管炎愈合程度、24h食管pH动态监测以及不良反应。结果治疗4周时埃索美拉唑与奥美拉唑临床有效率分别为82.5%和77.5%(P<0.05),食管炎改善总有效率分别为82.5%和75.5%(P>0.05)。8周时埃索美拉唑临床有效率明显增加﹙97.5%vs.90.0%,P<0.01),内镜下食管炎愈合率及总有效率也明显高于奥美拉唑组(分别为87.5%vs.80.0%和97.5%vs.92.5%,P﹤0.05)。24h食管pH监测结果显示,两组治疗后pH﹤4的反流次数和时间百分比明显降低(P﹤0.001),以埃索美拉唑组下降幅度更为明显。两组均无严重不良反应事件发生。结论埃索美拉唑能有效缓解老年人反流性食管炎的反流症状,治愈或减轻内镜下食管炎程度,抑酸效果好,安全可靠。<em>Objective To investigate and compare the effects and safety of esomeprazole and omeprazole in treating reflux esophagitis of the elderly patients. Methods Eighty patients with reflux esophagitis diaguosed by endoscope, aged 74.26 ± 6.64, wete randomly divided into two groups. Each group was treated with esomeprazole or omeprazole 20mg, twice a day, respectively. The improvement of symptoms and esophagitic degree were observed after administering the drugs for four and eight weeks. Continuous 24 hours esophageal pH recording was also performed. Results The symptom relief rates of esomeprazole and omeprazole arter four weeks of treatment were 82.5% and 77.5% （P〈0.05）. The efficiency rates of esophagitic degree were 82.5% and 75.5%. respectively （P〉0.05）. However, the esomeprazole group demonstrated a significantly greater efficacy than the omeprazole group（97.5% vs. 90.0%, P〈0.01） at the 8th week. They also had a better healing rate and efficiency rate of esophagitic degree （87.5% vs. 80.0% and 97.5% vs. 92.5%, P〈0.05, respectively）. After treatment, the number of total episndes and percentage of pH〈4 were lower than those before drug administration （P〈0.001）, especially those of the esomeprazole group. No obvious adverse events were observed in both groups. Conclusions Esomeprazole obviously relieves the symptom of reflux esophagitis in the elderly, and decreases the degree of reflux esophagitis or heals it. it also improves acid control. So it is a safe and effective medicine to treat reflux esophagitis of the aged.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/zk/search.aspx?key=K%3d%5b%e8%80%81%e5%b9%b4%e4%ba%ba%5d' title='老年人'>老年人</a> <a href='/subject/article.aspx?id=2094649' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e9%a3%9f%e7%ae%a1%e7%82%8e%5d' title='食管炎'>食管炎</a> <a href='/zk/search.aspx?key=K%3d%5b%e6%b6%88%e5%8c%96%e6%80%a7%5d' title='消化性'>消化性</a> <a href='/subject/article.aspx?id=7302771' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%9f%83%e7%b4%a2%e7%be%8e%e6%8b%89%e5%94%91%5d' title='埃索美拉唑'>埃索美拉唑</a> <a href='/subject/article.aspx?id=7341045' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%a5%a5%e7%be%8e%e6%8b%89%e5%94%91%5d' title='奥美拉唑'>奥美拉唑</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR571' title='R571'>R571</a>[<a href = '/domain/article.aspx?id=493' >医药卫生—消化系统</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=22178890" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=22178890"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); if (rd == "readdown") { var val = $("#hiddowninfo").val(); showdown(val); } $("#bdshare_js").attr("src","http://bdimg.share.baidu.com/static/js/bds_s_v2.js?cdnversion="+Math.ceil(new Date() / 3600000)); }) </script> <div class="layer-bg" style="display: none;"></div> <script type="text/javascript" src="/scripts/login.min.js"></script> <div class="layer-box login" id="divLoginBox" style="display: none;"> <div class="close"><a href="javascript:void(0);" id="btnLoginClose"> <img src="/images/layer-close.png" width="21" height="21" alt="" title="关闭" /></a></div> <h5 class="layer-title">用户登录</h5> <div class="layer-cnt"> <div class="search-list adv-object"> <div class="login-alert" id="divLoginError"></div> <div class="sinput"> <div class="input"><span class="user-ico"></span> <input type="text" id="txtLUsername" name="txtLUsername" maxlength="20"></div> </div> <div class="sinput"> <div class="input"><span class="psw-ico"></span> <input type="password" id="txtLPassword" name="txtLPassword" maxlength="20"></div> </div> <div class="submit"> <input type="button" value="登录" onclick="return normalLogin(loginAfter)" name="" class="btn-s"><input value="IP登录" onclick=" return ipLogin(loginAfter)" type="button" class="btn-c"> </div> </div> </div> </div> <div id="footer"> <p> 云南高校图书馆联盟文献共享服务平台 版权所有© <script type="text/javascript"> document.write(new Date().getFullYear()); </script> </p> <p> 您的IP：216.73.216.229 </p> </div> <input id="hifBaseLog" type="hidden" value="ODE2NzBYOzIyMTc4ODkwO1I1NzE7MDs7L2FydGljbGUvZGV0YWlsLmFzcHg="/> <script type="text/javascript"> $(document).ready(function () { $("#loginLoading").load("/user/loginheader.aspx?" + Math.random()); }); </script> <script> var _hmt = _hmt || []; (function () { var hm = document.createElement("script"); hm.src = "//hm.baidu.com/hm.js?36a05ff8f5e8a5be3ff03e1d75c8a9d1"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); </script> <script> (function (i, s, o, g, r, a, m) { i['GoogleAnalyticsObject'] = r; i[r] = i[r] || function () { (i[r].q = i[r].q || []).push(arguments) }, i[r].l = 1 * new Date(); a = s.createElement(o), m = s.getElementsByTagName(o)[0]; a.async = 1; a.src = g; m.parentNode.insertBefore(a, m) })(window, document, 'script', '//www.google-analytics.com/analytics.js', 'ga'); ga('create', 'UA-2219013-37', 'auto'); ga('send', 'pageview'); </script> </body> </html>