血清睾酮对轻中度老年男性痴呆患者认知功能的影响  被引量：2

THE INFLUENCE OF ENDOGENOUS TESTOSTERONE ON COGNITIVE FUNCTION IN ELDERLY MALE PATIENTS WITH MILD TO MODERATE DEMENTIA</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=22178894' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('uFVWzIhOtVkpCNpPX/FAsXpIUBymybSMSgYJbmcudh0=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="uFVWzIhOtVkpCNpPX/FAsXpIUBymybSMSgYJbmcudh0="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" name="collRemark" 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title='徐丽娟[1]'>徐丽娟[1]</a> <a href='/writer/article.aspx?id=100000000968855' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%8c%85%e4%bf%a1%e4%b8%80%5d' title='包信一[1]'>包信一[1]</a> <a href='/writer/article.aspx?id=100000009814360' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%ad%8f%e6%96%87%e7%9f%b3%5d' title='魏文石[1]'>魏文石[1]</a> <a href='/writer/article.aspx?id=100000002655834' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e4%b8%a5%e7%8e%89%e5%ae%81%5d' title='严玉宁[1]'>严玉宁[1]</a> <a href='/writer/article.aspx?id=100000005632414' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%bc%a0%e8%93%89%5d' title='张蓉[2]'>张蓉[2]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=517&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%8d%8e%e4%b8%9c%e5%8c%bb%e9%99%a2%e7%a5%9e%e7%bb%8f%e5%86%85%e7%a7%91' title='[1]华东医院神经内科,上海市200040'>[1]华东医院神经内科,上海市200040</a> <a href='/organ/article.aspx?id=517&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%8d%8e%e4%b8%9c%e5%8c%bb%e9%99%a2%e6%a0%b8%e5%8c%bb%e5%ad%a6%e7%a7%91' title='[2]华东医院核医学科,上海市200040'>[2]华东医院核医学科,上海市200040</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=81670X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e8%80%81%e5%b9%b4%e5%8c%bb%e5%ad%a6%e4%b8%8e%e4%bf%9d%e5%81%a5%5d' title='老年医学与保健'>《老年医学与保健》</a>2006年第2期102-103,109,共3页<em>Geriatrics & Health Care</em></p><p class='abstrack'><strong>摘　　要：</strong>目的探讨轻中度老年男性痴呆患者血清睾酮水平与认知功能的关系。方法研究对象为32例轻、中度阿尔茨海默病(AD)和30例轻、中度血管性痴呆(VaD)患者,用韦氏成人记忆量表(WMS)和简易精神状态量表(MMSE)进行认知功能检查,用放射免疫法测定血清睾酮浓度,应用多元线性回归分析各项认知功能与血清睾酮浓度的关系。结果轻、中度AD患者血清睾酮浓度与WMS的MQ值、MMSE总分有关(P<0.01),其中主要与视觉再生能力、视觉再认能力、延迟回忆力、地点定向力和语言能力有关(P<0.01,P<0.05)。轻、中度VaD患者血清睾酮水平也与MQ(P<0.01)、MMSE总分(P<0.05)有关,其中主要与触摸能力(P<0.01)、视觉再生能力、视觉再认能力、即刻记忆力和延迟回忆力有关(P<0.05)。结论血清睾酮水平可选择性影响男性轻、中度痴呆患者的认知功能,主要影响视空间和记忆等功能。<em>Objective To investigate the relationship between serum levels of endogenous testosterone （T） and cognitive functions in elderly male patients with mild to moderate dementia. Methods Thirty-two men with mild to moderate Alzheimer＇ s disease （AD） and thirty men with mild to moderate vascular dementia （VaD） were enrolled in this study. The cognitive functions of all patients were evaluated with Wechsler Memory Scale （WMS） and Mini Mental State Examination （MMSE）. Serum T concentration was measured by radioimmunological method. Multiple linear regression was performed to analyze the relation between each cognitive function and serum T. Results In AD group, serum T had statistical correlations with memory quotient （MQ） from WMS and overall MMSE score （P 〈 0.01）, especially with visual regeneration and visual recognition in WMS and delayed recall, place orientation and verbal abilities in MMSE （P 〈 0.01, P 〈 0.05）. In VaD group, serum T correlated with MQ （P 〈 0.01） and overall MMSE score （P 〈 0.05）, too. It was correlated with touch ability in WMS （P 〈 0.01）, and with visual regeneration and recognition within WMS as well as immediate and delayed recall within MMSE （P 〈 0.05）. Conclusions Serum T level had a selective relationship with cognitive functions in elderly male patients with mild to moderate dementia; it mainly affected visual and spatial abilities and memory.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/zk/search.aspx?key=K%3d%5b%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%5d' title='阿尔茨海默病'>阿尔茨海默病</a> <a href='/zk/search.aspx?key=K%3d%5b%e7%97%b4%e5%91%86%5d' title='痴呆'>痴呆</a> <a href='/zk/search.aspx?key=K%3d%5b%e8%a1%80%e7%ae%a1%e6%80%a7%5d' title='血管性'>血管性</a> <a href='/subject/article.aspx?id=3681000' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e7%9d%be%e9%85%ae%5d' title='睾酮'>睾酮</a> <a href='/zk/search.aspx?key=K%3d%5b%e8%ae%a4%e7%9f%a5%5d' title='认知'>认知</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR749.16' title='R749.16'>R749.16</a>[<a href = '/domain/article.aspx?id=504' >医药卫生—神经病学与精神病学</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=22178894" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=22178894"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); 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