出生前怀疑患有先天性肺囊性腺瘤样畸形新生儿的转归:1991—2001年的10年经验  

Outcome of antenatally suspected congenital cystic adenomatoid malformation of the lung: 10 Years'experience 1991-2001

作　　者：Calvert J.K. Boyd P.A. Chamberlain P.C. 郭战宏 

机构地区：[1]Neonatal Unit, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.Dr

出　　处：《世界核心医学期刊文摘（儿科学分册）》2006年第5期13-14,共2页

摘　　要：Objective: To determine the outcome of antenatally suspected congenital cystic adenomatoid malformation of the lung (CCAM) over a 10 year period. Methods: Thi s is a retrospective study of all babies diagnosed antenatally in the Prenatal D iagnosis Unit and delivered in Oxford between 1991 and 2001. Data were obtained from the Oxford Congenital Anomaly Register, theatre records, and histopathology reports. Results: Twenty eight cases of CCAM were diagnosed antenatally. Five p regnancies were terminated. Data are available on all 23 of the pregnancies that continued and resulted in two neonatal deaths and 21 surviving babies. Eleven o f the 23 cases (48%) showed some regression of the lesion antenatally, and four of these cases appeared to resolve completely on prenatal ultrasound. Three of the 23 babies (13%) were symptomatic in the early neonatal period, and three de veloped symptoms shortly afterwards. Seventeen of the 23 babies (74%) were asym ptomatic, of whom 12 had abnormalities on chest radiograph or computed tomograph y scan and had elective surgery. Two babies (8%) had completely normal postnata l imaging, and three had abnormalities which resolved in the first year of life. Seventeen of the 23 babies (74%) had surgery. Histology at surgery was heterog eneous. Of the 23 live births, all 21 survivors (91%) are well at follow up or have been discharged. Conclusions: All babies diagnosed antenatally with CCAM re quire postnatal imaging with computed tomography irrespective of signs of antena tal resolution. In asymptomatic infants, the recommendations are close follow up and elective surgery for persistent lesions within the first year of life. Hist ology at surgery was heterogeneous, and this should be considered when counselli ng parents.Objective： To determine the outcome of antenatally suspected congenital cystic adenomatoid malformation of the lung （CCAM） over a 10 year period. Methods： This is a retrospective study of all babies diagnosed antenatally in the Prenatal Diagnosis Unit and delivered in Oxford between 1991 and 2001. Data were obtained from the Oxford Congenital Anomaly Register, theatre records, and histopathology reports.

关 键 词：先天性肺囊性腺瘤样畸形 新生儿死亡 出生前 转归 产前诊断 婴儿存活 先天性异常 10年间 病理报告 

分 类 号：R734.2[医药卫生—肿瘤] R722[医药卫生—临床医学]