奥扎格雷中DMF残留量的测定  

On determination of residual amount of DMF in ozagrel by capillary GC

作　　者：陈改敏[1] 闫学斌[1] 李雯[2] 李惠举[1] 姬小明[1] 

机构地区：[1]郑州大学化学系新药研究开发中心,河南郑州450052 [2]郑州大学化工系,河南郑州450002

出　　处：《南阳师范学院学报》2006年第6期55-57,共3页Journal of Nanyang Normal University

摘　　要：建立了直接进样毛细管气相色谱法测定奥扎格雷中DMF残留量的方法。色谱柱为HP-FFAP石英毛细管柱。采用程序升温，载气为氮气，检测器为FID，以DMSO为溶剂。在上述色谱条件下，DMF的线性范围为1．76-15．84mg／L，平均加样回收率为95．14％。此方法可用于测定原料药中DMF的残留量。A capillary gas chromatographic method with directly sampling was established to determination the residual amount of DMF in ozagrel. The analytical column was HP - FFAP capillary quartz column. The column temperature was programmed. The carrier gas was nitrogen. The detector was FID. DMSO was selected as solvent. The linear range for DMF was 1.76- 15.84 mg/L. The average recovery of them was 95.14%. In conclusion, the method was simple, rapidly, special, precision and it could be used for the determination of the residual amount of DMF in drug substances.

关 键 词：毛细管气相色谱法 奥扎格雷 残留溶剂 DMF 

分 类 号：O657.71[理学—分析化学]