基质金属蛋白酶及其组织抑制物在子宫内膜癌中的表达  

Expression of matrix metalloproteinase-9 and it's tissue inhibitor-1 in endometrial carcinoma

作　　者：黄素真[1] 罗湘闽[1] 吴春林[2] 黄种心[2] 

机构地区：[1]福建医科大学附属二院妇产科,泉州362000 [2]福建医科大学附属二院病理科

出　　处：《实用肿瘤学杂志》2006年第3期190-192,共3页Practical Oncology Journal

摘　　要：目的 研究基质金属蛋白酶（MMP）-9及其组织抑制物（TIMP）-1在子宫内膜癌组织中的表达及其临床病理学意义。方法 应用链霉素抗生物素蛋白-过氧化物酶免疫组织化学方法对40例子宫内膜癌组织及10例正常子宫内膜组织中MMP-9及TIMP-1蛋白及活性进行检测。结果 子宫内膜癌组织中MMP-9及TIMP-1的阳性率高于正常子宫内膜，差异有显著性。组织学分级为C3的子宫内膜癌组织中MMP-9和TIMP-1的表达水平高于C2和G1，手术病理分期Ⅱ-Ⅲ期的子宫内膜癌组织中MMP-9和TIMP-1的表达水平高于Ⅰ期。结论 子宫内膜癌组织中MMP-9和TIMP-1的表达随着组织学分级和手术病理分期的升高而增加。Objective To study the expression of matrix metalloproteinase （MMP） - 9 and tissue inhibitor of metalloproteinase （TIMP） - 1 protein in human endometrial carcinoma tissue and its corelation with clinicopathologicol features. Methods Imrnunohistochemistry technique was used to measure the MMP-9 and TIMP - 1 protein levels and activities in endometrial carcinoma tissue of 40 patients and control group composed of 10 normal endometrial samples. Results The positive expression of MMP- 9 and TIMP - 1 proteins in endometrial carcinoma tissue were higher than those in normal endometrial samples. MMP - 9 and TIMP-1 expression levels in grade Ⅲ carcinoma tissues were higher than those in grade Ⅱ- and Ⅰ . They were also higher in stage Ⅱ- and Ⅲ carcinoma tissues than those in stage Ⅰ . Conclusion MMP - 9 and TIMP - 1 expression levels in endometrial carcinoma correlate with the histologic grade and surgical - pathological stage.

关 键 词：子宫内膜肿瘤 基质金属蛋白酶类 基质金属蛋白酶类抑制剂 

分 类 号：R737.33[医药卫生—肿瘤]