p53基因突变与肺癌发生的早期遗传学损害  

MUTATION OF p53 GENE MAY BE AN EARLY GENETIC ALTERATION IN LUNG CANCER DEVELOPMENT

作　　者：喻伦银[1] 王虹[1] 毕勇毅[1] 刘铭球[1] 邹祖玉[1] 张正彬[1] 

机构地区：[1]湖北医科大学病理学教研室

出　　处：《中华医学遗传学杂志》1996年第3期161-163,共3页Chinese Journal of Medical Genetics

基　　金：湖北省科委"八五"重点科技项目

摘　　要：在进行肺癌与ｐ５３基因关系的系列研究过程中，发现１例支气管粘膜上皮不典型增生和１例原位癌，运用免疫组织化学方法进行ｐ５３蛋白表达检测，结果发现支气管上皮不典型增生和原位癌组织中有明显的ｐ５３蛋白阳性染色细胞，从而进一步证实了ｐ５３基因突变可能是肺癌发生的早期遗传学损害。A number of studies have revealed that the mutation of p53 gene and overexpression of p53 protein can be seen in many malignant tumors; therefore, it is thought that the inactivation of p53 gene is one of the most common molecular abnormalities in human cancers. But it is not fully understood that the mutation of p53 gene is an early genetic alteration or late genetic event in cancer development. In this study, a case of dysplasia of broncheal mucosa epihelium and a case of carcinoma in situ of the lung were studied to observe the expression of p53 protein with immunohistochemical method.Significant p53-positive staining cells were seen in both lesions. These findings have further demonstrated that the mutation of p53 gene is an early genetic alteration in the development of lung cancer.

关 键 词：肺肿瘤 癌前损害 P53基因 

分 类 号：R734.202[医药卫生—肿瘤]