涎腺腺样囊性癌过继免疫治疗的实验研究γlFN与TNFα对LAK细胞涎腺腺样囊性癌细胞的杀伤活性及可能机制  

Experimental study of adoptive immunotherapy for oral adenoid cystic carcinoma Effect of γIFN and TNFα on LAK cytotoxicity against ACC-2 and its possible mechanism

作　　者：李笑梅[1] 彭玉田[1] 周中华[1] 杨振群[1] 

机构地区：[1]第二军医大学长海医院口腔科

出　　处：《实用口腔医学杂志》1996年第2期96-98,共3页Journal of Practical Stomatology

摘　　要：通过体外实验观察了当γ干扰素（γｌＦＮ）和肿瘤坏死因子α（ＴＮＦα）作用于ＬＡＫ细胞（淋巴因子激活杀伤细胞）诱导阶段时对ＬＡＫ细胞杀伤涎腺腺样囊性癌细胞系２（ＡＣＣ－２）活性的影响。结果显示：ＴＮＦα可以提高低剂量白介素—２（ｌＬ－２）诱导的ＬＡＫ细胞杀伤活性，且对ＡＣＣ－２的杀伤活性要高于Ｒａｊｉ，增强作用的产生与它对ＬＡＫ细胞增殖的影响无关。γｌＦＮ可以呈剂量依赖性地抑制ＬＡＫ细胞杀伤活性。The effects of γIFN and TNFα on the proliferation of LAK cells and LAK cytotoxicity against ACC-2 when they act at the induction of LAK cells were atudied in vitro. The results show that TNFα can be a suitable enhancer to augment IL 2 induced LAK cytotoxicity against ACC 2. This synergism has nothing to do with the effect of TNFα on the proliferation of LAK cells; γIFN can lightly inhibit LAK activity. This inhibition on LAK cytotoxicity may be related to the reduction of LAK cells.

关 键 词：腺样囊性癌 免疫疗法 涎腺肿瘤 

分 类 号：R739.870.5[医药卫生—肿瘤]