闭角型青光眼外周血T细胞亚群的表达  

T cell subset expression in the peripheral blood of angle-closure glaucoma patients

作　　者：朱宝义[1] 王为农[1] 潘小凤[1] 

机构地区：[1]第四军医大学唐都医院眼科,中国陕西省西安市710038

出　　处：《国际眼科杂志》2006年第3期618-619,共2页International Eye Science

摘　　要：目的:利用单克隆抗体技术检测闭角型青光眼(ACG)患者外周血T细胞亚群,以了解ACG患者机体的整体免疫平衡状态。方法:使用单克隆抗体的碱性磷酸酶抗碱性磷酸酶法(A-PAAP)检测45例闭角型青光眼(ACG)患者外周血T细胞亚群,并配组对照分析。结果:ACG组的CD3+细胞的百分比数均低于对照组(ACGvs对照组P<0.005),CD4+和CD8+细胞的百分比数高于对照组(ACGvs对照组P<0.01和P<0.001),CD4+/CD8+的比值低于对照组(ACGvs对照组P<0.001)。结论:ACG患者机体存在着自身免疫调节功能的紊乱,且可能是引发疾病发生的一种因素。AIM： To understand the whole immunologic balance state of the body of angle-closure glaucoma （ACG） patient by testing T cell subset in the peripheral blood of ACG patient with monoclonal antibody technique. METHODS： T cell subsets in the peripheral blood of 45 ACG patients were tested with alkaline phosphatase-antialkaline phosphatase （APAAP） method of monoclonal antibody technique and analyzed with matched control. RESULTS： The percentage of CD3＋ cells of ACG group was lower than that of control group （P 〈0.005）,the percentages of CD＋ cells and CD8＋ cells of ACG group were higher than those of control group （P〈0.01 and P〈0.001） and the CD4＋/CD8＋ ratio of ACG group was lower than that of control group （P〈0.001）. CONCLUSION： Autoimmuno-regulatory dysfunction exists in the body of ACG patient and may be one of the factors initiating the occurrence of the disease.

关 键 词：闭角型青光眼 T细胞亚群 

分 类 号：R775[医药卫生—眼科]