气道内置入^(125)Ⅰ粒子治疗癌性肺不张  

Malignant Atelectasis Treated by Endobronchial Brachytherapy with 125Ⅰ Seeds

作　　者：金普乐[1] 王敏[1] 郭丽娟[1] 

机构地区：[1]河北医科大学第四医院呼吸科,石家庄市050011

出　　处：《中国肿瘤临床》2006年第12期696-698,共3页Chinese Journal of Clinical Oncology

基　　金：河北省卫生厅科研基金项目资助(编号:04034)

摘　　要：目的:探讨气道内置入125I粒子治疗癌性肺不张的疗效和不良反应。方法:采用环甲膜穿刺、置管、气道内悬挂125I放射性微粒子,对癌性肺不张进行持续近距离放疗,治疗时间3个月。结果:9例癌性肺不张患者中,肺复张4例,有效率44%;患者咳嗽、咯血和胸痛有不同程度的缓解5例;颈部瘘口炎性肉芽组织增生2例、喉部不适1例。结论:经环甲膜穿刺,气道内悬挂125I粒子对于治疗癌性肺不张简便、安全、有效。Objective： To evaluate the efficacy and safety of endobronchial brachytherapy for malignant airway obstruction with ^125Ⅰ seeds. Methods： Patients with malignant atelectasis underwent endobronchial brachytherapy with ^125Ⅰ seeds implanted via cricothyroid membrane puncture that were then suspended in the airway, guided by fibreoptic bronchoscopy. The treatment time was three months. Results： Of the 9 cases, 4 patients got complete relief, making the effective rate 44%. Cough, hemoptysis and chest pain occurred in 5 patients. Complications such as inflammatory granuloma in the neck and laryngeal malaise occurred in 2 patients and 1 patient, respectively. Conclusion： Endobronchial brachytherapy with ^125Ⅰ seeds for cancerous atelectasis is simple, safe and effective.

关 键 词：^125Ⅰ粒子 腔内放疗 癌性肺不张 

分 类 号：R734.2[医药卫生—肿瘤]