胃癌中MMP-2表达及淋巴管密度与淋巴结转移的关系  

Expression of MMP - 2 in gastric carcinoma

作　　者：刘洋[1] 王兴民[2] 

机构地区：[1]山东省潍坊医学院,261042 [2]山东省益都卫生学校,262500

出　　处：《中华腹部疾病杂志》2006年第6期399-402,共4页Chinese Journal of Celiopathy

摘　　要：目的 探讨胃癌组织中基质金属蛋白酶-2（MMP-2）的表达及淋巴管密度与淋巴结转移的关系。方法 收集根治性手术切除的68例胃癌原发病标本，同时选取10例胃良性病变的正常胃组织标本，应用免疫组织化学SP法检测MMP-2在胃癌组织和正常胃组织中的表达水平及淋巴管密度的高低。结果 MMP-2蛋白、淋巴管密度在胃癌组织和正常胃黏膜组织中的表达差异育显著性，具有统计学意义（P〈0．001）。MMP-2、淋巴管密度在伴有淋巴结转移的胃癌中的表达较无淋巴结转移的胃癌中的表达在统计学上有显著性差异（P〈0．001）。MMP-2的表达、淋巴管密度与胃癌浸润深度、TNM分期、肿瘤分化程度、临床分期及淋巴结转移密切相关。MMP-2的表达与淋巴管密度的高低呈正相关（rs=0．663）。结论 胃癌组织中MMP-2蛋白的表达、淋巴管密度和胃癌浸润深度、TNM分期、肿瘤分化程度、临床分期及淋巴结转移密切相关。MMP-2抑制剂及VEGFR-3抑制剂的研究将为抗肿瘤淋巴转移的治疗开辟一条新途径。AIM To study the expression of matrix metalloproteinase-2 （MMP-2） in gastric carcinoma and its association with pathologic features. METHODS Immunohistochemical method was employed to investigate the expression of MMP - 2 and VEGER - 3 in tissue blocks from 68 gastric carcinomas and 10 normal surgical specimens. RESULTS MMP - 2 expression was positive in 52. 9% of the carcinomas but in 10.0% of the normal specimens（ P 〈0. 001）LMVD according to VEGFR - 3 was higher in carcinomas than in normal tissue （4.91 ± 1.90/200 vs 2.25 ± 0.35/200, P 〈 0. 001 ）. MMP - 2 expression was positively correlated with LMVD, lymphatic infiltration,and remote metastasis （ P 〈 0. 001）. CONCLUSIONS The overexpression of MMP- 2 and high LMVD are characteristics of gastric carcinoma,which may provide some potential target points for the treatment of gastric carcinoma.

关 键 词：胃癌 基质金属蛋白酶-2 淋巴管密度 淋巴结转移 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]