脑血管病患者蛋白C系统和纤溶系统的变化及干预治疗  

A Study on the Changes of Protein C and Fibrinolytic System in Patients with Cerebrovasculer Disease and Intervened Treatment

作　　者：汪颜[1] 牛世芹[1] 陈宇丹[1] 徐纪华[1] 胡文立[1] 

机构地区：[1]首都医科大学附属北京朝阳医院神经内科,100020

出　　处：《医学研究杂志》2006年第6期38-40,共3页Journal of Medical Research

摘　　要：目的探讨急性脑血管病患者蛋白C系统和纤溶系统的变化及急性脑梗死干预治疗对其影响。方法测定急性脑血管病患者、正常对照者血浆蛋白C(PC)、蛋白S(PS)、血栓调节蛋白(TM)、组织纤溶酶原激活物(t-PA)、组织纤溶酶原激活制物(PAI)的水平,并对急性脑梗死患者经治疗后再测定这些项目。结果急性脑梗死组PC、PS明显低于其他各组,急性脑梗死患者治疗后有所升高,急性脑出血、腔隙性脑梗死组与正常对照组相比无显著性差异;急性脑出血、急性脑梗死组(TM)均明显高于腔隙性脑梗死组及正常对照组,急性脑梗死患者治疗后有所降低;急性脑梗死组t-PA低于正常对照组,而急性脑出血组升高,急性脑梗死患者治疗后有所升高;急性脑梗死组PAI明显高于正常对照组,急性脑出血、腔隙性脑梗死组分别与正常对照组相比有所升高,急性脑梗死患者在治疗后有所降低。结论急性脑血管病患者存在着明显的凝血和纤溶异常,测定PC、PS、TM、t-PA、PAI对判断卒中的类型、严重程度、疗效、预后具有重要价值,早期干预治疗具有重要意义。Objective To investigate the changes of protein C and fibrinolytic system in patients with acute cerebrovasculer disease and the influence of intervened treatments on acute cerebral infarction （ACI） . Methods Determinations of protein C （PC）, protein S （IX3）, thrombomodulin （TM）, Tissue- type plasminogen activater （t- PA）, plasminogen activator inhabitor （PM） were performed in patiens with acute cerebrovasculer disease and normal control （NC）, then redeterminated these items after treatments in patients with A CI. Results PC,PS： The levels in patients with ACI were significantly lower than that in other groups.After dreatments, the levels in patients with ACI increased.There were no significantly discrepancy in acute cerebral hemorrhage （ACH） and lacunar cerebral infarct （LCI） compared with NC; TM： The levels in patients with ACH, ACI were significantly higher than that with LCI and NC. After dreatments, the levels in patients with ACI decreased; t - PA： The levels in patients with ACI were lower than NC, whereas the levds in patients with ACH increased.After dreatments, the levels in patients with ACI increased; PAI： The levels in patients with ACI were significantly higher than NC, and also found that the levels in patients with ACH and LCH were higher compared with NC. The levels in patients with ACI decreased after dreatments. Conclusions There are obviously abnormalities in plasma coagulative and fibrinlytic parameters in acute cerebrovasculer disease; To check the levels of PC, PS, TM, t - PA, PM are important to predict the type of stroke, the seriousness of disease, the effect of treatment, prognosis of the cases and suggest that earlier treatments be important.

关 键 词：急性脑梗死 急性脑出血 腔隙性脑梗死 蛋白C系统 纤溶系统 

分 类 号：R743[医药卫生—神经病学与精神病学] R562.25[医药卫生—临床医学]