抑癌基因PTEN在人食管鳞癌中的表达及其意义  

Expression and significance of PTEN in esophageal squamous cell carcinomas

作　　者：赵晖[1] 丛波[1] 彭书华[1] 

机构地区：[1]山东大学齐鲁医院胸外科,济南250012

出　　处：《中华消化内镜杂志》2006年第3期194-196,共3页Chinese Journal of Digestive Endoscopy

基　　金：山东省卫生厅基金资助(2003HW077)

摘　　要：目的研究食管鳞癌中PTEN的表达,探讨其与临床病理参数的关系及对患者预后的判断价值。方法应用免疫组织化学S-P法检测62例食管鳞癌组织标本中PTEN的表达水平。结果(1)PTEN的表达与食管壁浸润程度、淋巴结转移情况、远处转移情况、pTNM分期、肿瘤分化程度呈负相关关系(P＜0．05)。(2)高表达组患者的术后3年生存率明显低于低表达组,组间比较有统计学意义(P＜0．01)。结论PTEN表达与反映食管鳞癌恶性度的临床病理参数呈负相关关系,是独立的预后评价因素之一。Objective To study on the relationship of PTEN with clinicopathological parameters and prognosis of esophageal squamous cell carcinoma patients. Methods The expression of PTEN was detected in 62 cases of esophageal squamous cell carcinomas by immunohistochemistry. Results （ 1 ） PTEN expression is negatively correlated with the depth of invasion, lymph node metastasis, distant metastasis, pTNM stage and degree of differentiation. （ 2 ） The difference of survival is significant between high and low expression groups. Conclusion PTEN is correlated negatively with the clinicopathological parameters reflecting the malignant biological behavior,and is one of the significant prognostic predictors by univariate analysis.

关 键 词：食管肿瘤 基因 预后 

分 类 号：R735.1[医药卫生—肿瘤]