FcγRⅢB基因多态性与汉族人群慢性牙周炎关系的研究  

Association of FcγRⅢB gene polymorphisms with susceptibility to chronic periodontitis in Chinese patients

作　　者：庞若愚[1] 陈开云[2] 章锦才[1] 张雄[1] 徐琛蓉[1] 

机构地区：[1]广东省口腔医院牙周科,广州510280 [2]中山大学光华口腔医院正畸科,广州510055

出　　处：《口腔医学》2006年第3期164-166,共3页Stomatology

基　　金：广东省医学科学技术研究基金资助项目(A2003113)

摘　　要：目的探讨FcγRⅢB基因多态性与慢性牙周炎敏感性的关系。方法收集63例重度慢性牙周炎患者、103例轻中度慢性牙周炎患者及80名健康对照者的颊黏膜拭子,提取DNA,采用等位基因特异性引物PCR(PASA)法测定FcγRⅢB基因多态性,比较各组间基因型分布的差异。结果FcγRⅢB基因型分布及等位基因频率在3组间差异无显著性。结论研究未显示FcγRⅢB基因型与慢性牙周炎相关。Objective To investigate the relationship between B gene polyraorphisms and susceptibility to chronic periodontitis in Chinese patients. Methods DNA samples with buccal swabs were collected from 63 severe CP patients, 103 initial to moderate CP patients, and 80 healthy controls in Chinese Han nationality. The FcγRⅢB gene polyraorphisms were analyzed with PASA. Results There were no significant genotype distribution differences of FcγRⅢB between any two of the three subject groups. Conclusion Further study was needed since we did no find the relationship between the B gene polymorphism and periodontitis in this present study.

关 键 词：慢性牙周炎 FcγRⅢB 基因多态性 疾病敏感性 

分 类 号：R781.42[医药卫生—口腔医学]