肝癌患者纤维蛋白原和D-二聚体的检测及其临床意义  

Clinical Significance of Plasma Fibrinogen and D-Dimer Test in Liver Carcinoma

作　　者：吴宗勇[1] 齐军[1] 赵国华[1] 贾德强[1] 张振杰[1] 穆建军[1] 杜莹[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院检验科,北京100021

出　　处：《标记免疫分析与临床》2006年第2期68-69,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：通过检测肝癌患者血浆中的纤维蛋白原(Fib)和D二聚体,探讨肝癌患者Fib和D二聚体与肝细胞癌的分化程度以及转移与否的关系,评价其在肝癌辅助诊断中的临床意义。使用sysmexCA7000血凝分析仪检测50名正常人、64例肝良性肿瘤患者、136例肝细胞癌患者和40例转移性肝癌患者血浆中的Fib和D二聚体。正常人、肝良性肿瘤、肝细胞癌及转移性肝癌患者血浆中的Fib和D二聚体的结果分别为2.90±0.50、2.71±0.67、2.14±0.71、3.45±0.73g/L和162±81、251±134、242±153、342±159μg/L;在肝细胞癌EdmondsonⅠ、Ⅱ、Ⅲ、Ⅳ级的值分别为2.03±0.40、2.15±0.42、2.51±0.45、2.61±0.47g/L和164±112、173±145、289±146、86±46μg/L。肝细胞癌患者血浆Fib明显低于正常人(P<0.01),而D二聚体明显高于正常人(P<0.01);组织学分级越高Fib有升高的趋势;转移性肝癌患者的Fib和D二聚体都明显高于未转移者(P<0.01)。结论是肝细胞癌患者血浆Fib含量降低,而D二聚体含量升高;转移性肝癌患者的Fib和D二聚体含量均升高。To study clinical significance of plasma fibrinogen（Fib） and D-Dimer test in the differentiation, metastasis and accessory diagnosis in hepatocellular carcinoma, the level of plasma Fib and D-Dimer were measured by blood coagulation analyzer sysmex CA-7000 in 50 healthy samples, 64 patients with benign liver tumor, 136 patients with hepatocellular carcinoma and 40 patients with metastatic liver carcinoma. The mean levels of Fib and D-Dimer in healthy samples and in benign liver, hepatocellular and metastatic liver carcinoma patients were 2. 90± 0. 50,2. 71±0. 67,2. 14±0.71,3.45±0. 73 g/L and 162±81,251±134,242±153,342±159μg/ L respectively. The mean levels of Fib and D-Dimer in hepatocellular Edmondson Ⅰ , Ⅱ , Ⅲ and Ⅳ were 2. 03±0.40,2.15±0. 42,2.51±0.45,2. 61±0.47g/L and 164±112,173±145,289± 146,86±46μg/L respectively. The level of Plasma Fib in hepatocellular carcinoma group was significantly lower than that in healthy group（P〈0.01）, but D-Dimer was higher（P〈0.01）. Fib increased with tissue grading number increasing. Fib and D-Dimer increased more significantly in metastasis carcinoma group than in non-metastasis group（P〈0.01）. The level of plasma Fib in hepatocellular carcinoma group decreased, but D-Dimer increased, while both Fib and D-Dimer increased in metastasis carcinoma group.

关 键 词：肝癌/诊断 纤维蛋白原 D-二聚体 

分 类 号：R735.7[医药卫生—肿瘤]