慢性HBV感染血清HBV　DNA五项指标及肝病理之间的相关性分析  

A STUDY OF RELATIVITY AMONG HBV DNA FIVE ITEMS IN SERA AND HEPATIC PATHOLOGY FROM PATIENTS WITH CHRONIC HBV INFECTION

作　　者：洪丰[1] 邵珠艳[1] 赵洪涛 潘红娜 杨晓春 

机构地区：[1]济宁医学院第一教学医院,济宁医学院,山东省立医院,山东省医科院

出　　处：《济宁医学院学报》1996年第2期10-12,共3页Journal of Jining Medical University

摘　　要：用ＰＣＲ检测了ＨＢＶ标志不同状态１０２例，均经肝活检诊断，其中慢性迂延性肝炎（ＣＰＨ）７４例，慢性活动性肝炎（ＣＡＨ）２１例，肝组织正常７例。结果：ＨＢｓＡｇ阳性率ＣＡＨ为８５．７％，显著高于ＣＰＨ４７．３％（Ｐ＜０．０１）；抗－ＨＢｓ阳性率ＣＰＨ为１８．９％，明显高于ＣＡＨ４．７％。ＰＣＲ血清ＨＢＶＤＮＡ总阳性率分别为ＣＰＨ８３．８％、ＣＡＨ８５．７％。在抗－ＨＢｅ阳性的血清ＨＢＶＤＮＡ检出率ＣＰＨ９０．５％，ＣＡＨ８５．７％。抗－ＨＢｓ阳性血清ＨＢＶＤＮＡ检出率ＣＰＨ为４４．４％，提示抗－ＨＢｅ和抗－ＨＢｓ阳性不仅不能代表ＨＢＶ复制停止或已被消除，而且肝脏仍可处于炎症状态。We detected 102 patients with different HBV five items using polymerase chain reaction assay.All donors were diagnosed by hepatic biopsy,in whom 74 cases of chronic persistent hepatitis(CPH),21 cases of chronic active hepatits(CAH) as well as 7 cases of normal hepatic tissus.The results showed that:of 85.7% CAH patients positive for HBV surface antigen(HBsAg),signifieantly higher than CPH patients,in whom positive rate is 47.3%(P<0.01).Of 18.9%CPH patients positive for antibody agains HBV surface antigen,significantly higher than CAH patients,in whom positive rate is 4.7%,Of all cases,83.8% CPH and 85.7% CAH patients were positive for HBV DNA in sera by PCR.Of sera with positive antibody against HBVe antigen,90.5% CPH and 85.7% CAH patients were positive for HBV DNA.Of sera with positive antibody against HBV surface antigen.44.4% CPH patients were positive for HBV DNA,this indicated that both positive antibody against HBV surface antigen and antibody against HBVe antigen couldn't tell the cancelation or stop of replication of HBV,the hepatic tissue might be still in inflammtory state.

关 键 词：乙型肝炎 聚合酶链反应 病理学 HBV DNA 

分 类 号：R512.620.2[医药卫生—内科学]