大鼠C6脑胶质瘤X刀治疗及其急性治疗反应的实验研究  

Treatment of rat C6 gliomas with X-knife and its acute therapeutic effects

作　　者：关丽明[1] 夏兵[2] 郭敏[1] 徐克[1] 赵宇[1] 徐炳学[2] 张朔[2] 姚雷[2] 段红杨 

机构地区：[1]中国医科大学附属第一医院放射科,沈阳110001 [2]中国医科大学附属第一医院放射肿瘤科,沈阳110001 [3]中国航空部中心医院放射科

出　　处：《中华放射医学与防护杂志》2006年第3期261-263,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的探讨采用CT靶点定位给予大鼠C6脑胶质瘤X刀治疗的可行性及其急性期治疗反应。方法采用立体定向方法制作大鼠C6脑胶质瘤模型,并于C6细胞植入后16d采用不同扫描野、平扫和增强相结合的CT靶点定位方法给予20GyX刀治疗,并观察其急性期治疗反应。结果治疗组(7只荷瘤鼠)X刀治疗均成功,5只生存状态均好于肿瘤组(9只荷瘤鼠)。治疗组肿瘤细胞密度减低和肿瘤水肿的发生率明显高于肿瘤组(P<0·05),同时伴有血管生成减少。结论本组CT靶点定位方法将在鼠脑肿瘤立体定向放射外科(SRS)研究中发挥重要作用。Objective To study the feasibility of target positioning in X-knife treatment on rat C6 gliomas and its acute therapeutic effects on the tumor. Methods To established animal model C6 cells were inoculated into the right caudate nucleus for 20 Wistar rats by stereotactic procedure. On the 16th day after inoculation of C6 cells, tumor-bearing rats were treated with X-knife, 5 mm collimator and combination CT plain images with large field to the enhancement images of small field based on the latter was used to sketch the target position through the 3D workstation,20 Gy in total. The acute therapeutic effect of X-knife treatment was evaluated with comparison to conditions of the rats in the tumor group. Results There were 7 tumor-bearing rats in the treatment group, and two rats died at 1 hour and 3 days later; the remaining 5 rats were executed 5 days later. The overall conditions of 5 rats in the treatment group were much better than those in the tumor group （7 rats）. Angiogenesis decresaing and hypocellular regions and tumor edema were observed more frequently in the treatment group that those in the tumor group （P 〈 0.05）. Conclusion The method of target positioning with computerd tomography will play an improtant pole in further study on stereotactic radiosurgery of brain tumors in rats.

关 键 词：脑胶质瘤 放射外科 体层射影术 X线计算机 大鼠 

分 类 号：R739.4[医药卫生—肿瘤]