吸入甲醛对小鼠精子畸形率和骨髓细胞微核率的影响  

The Effect of Formaldehyde by Inhalation on the Sperm Toxicity and Micronucleated Cell in Mice

作　　者：童智敏[1] 朱士新[1] 施健[1] 杨红[2] 孔璐[2] 姜荣明[1] 赵进顺[2] 

机构地区：[1]江苏省昆山市疾病预防控制中心,江苏昆山215301 [2]东南大学公共卫生学院,江苏南京210009

出　　处：《预防医学论坛》2006年第4期391-393,共3页Preventive Medicine Tribune

基　　金：昆山市科学技术局(KS0521)

摘　　要：[目的]探讨吸入甲醛对小鼠生殖细胞和体细胞的遗传毒性作用。[方法]用不同剂量(5.18g/m3、2.59g/m3、1.29g/m3)的甲醛静式吸入染毒小鼠5d和4d,均于末次染毒24h后颈椎脱臼处死小鼠,观察甲醛对小鼠精子畸形率和骨髓细胞微核率的影响。[结果]高剂量组的精子畸形率为3.88%,微核率为8.63‰,均超过正常值,且与阴性对照组比较差异均有统计学意义(P<0.05)。[结论]吸入一定浓度的甲醛对小鼠生殖细胞和体细胞具有致遗传毒性作用。[Objective]To explore the effect of formaldehyde on the sperm toxicity and micronucleated cell. [Methods] Kunming mice were administered with 5.18 g/m^3 , 2.59 g/m^3 , 1.29 g/m^3 formaldehyde by inhalation respectively for 4 and 5 days. The mice were killed after 24 h at the last exposure to formaldehyde,the morphology of sperm and the effect on polychromatic erythrocyte （PCE） were investigated. [Results]The sperm deformation and micronucleus ratios exposed to the highest concentration formaldehyde were 3. 88% ,8. 63‰ respectively,and both of them had remarkable significance compared with the control groups. [Conclusion]This experiment showed that formaldehyde might have reproduction toxicity and genotoxicity to mice.

关 键 词：甲醛 精子畸形 微核 

分 类 号：R114[医药卫生—卫生毒理学]