预防性激光治疗单侧年龄相关性黄斑病变促进脉络膜新生血管形成:玻璃膜疣激光研究的最终结果  

Prophylactic laser treatment hastens choroidal neovascularization in unilateral age-related maculopathy:Final results of the Drusen Laser Study

作　　者：Owens S.L. Bunce C. Brannon A.J. 潘佳鸿 

机构地区：[1]Professorial Unit, Moorfields Eye Hospital, City Road, London EC1V2PD,UnitedKingdom Dr.

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第5期9-9,共1页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：PURPOSE: The Drusen Laser Study evaluated macular laser to prevent choroidal neovascularization (CNV) and vision loss in high-risk age-related maculopathy (ARM). DESIGN: Prospective, interventional, randomized, controlled clinical trial in five hospital centers. METHODS: Patients in the unilateral group had neovascular ARM and drusen in the study eye. Study eyes were randomized to laser-treated or no-laser groups. For patients in the bilateral drusen group, eyes were randomized to right eye, laser or no laser; and left eye, alternative. Laser treatment comprised 12 argon spots. Outcome was best-corrected visual acuity and CNV signs, which were monitored for 3 years. RESULTS: In the unilateral group, vision loss occurred in 21 (28.8%) of 73 patients in laser vs 13 (19.7%) of 66 no-laser patients (P=.214). Incidence of CNV was 27 (29.7%) of 91 in laser vs 15 (17.65%) of 85 no-laser patients (P=.061). CNV onset was approximately 6 months earlier in laser-treated compared with no-laser patients (P=.05). In the bilateral group, vision loss occurred in six (8.3%)-of 72 laser-treated vs 10 (13.9%) of 72 fellow eyes (P=.3877). CNV incidence was 12 (11.6%) of 103 in laser-treated vs seven (6.8%) of 103 fellow eyes (P=.225). There was no difference in onset of CNV. CONCLUSIONS: Results do not support prophylactic laser of the fello weye of patients with neovascular ARM. Its role in patients with bilateral drusen remains unclear.PURPOSE： The Drusen Laser Study evaluated macular laser to prevent choroidal neovascularization （CNV） and vision loss in high-risk age-related maculopathy （ARM）. DESIGN： Prospective, interventional, randomized, controlled clinical trial in five hospital centers. METHODS： Patients in the unilateral group had neovascular ARM and drusen in the study eye. Study eyes were randomized to laser-treated or no-laser groups. For patients in the bilateral drusen group, eyes were randomized to right eye, laser or no laser; and left eye, alternative. Laser treatment comprised 12 argon spots. Outcome was best-corrected visual acuity and CNV signs, which were monitored for 3 years. RESULTS： In the unilateral group, vision loss occurred in 21.

关 键 词：预防性激光治疗 年龄相关性黄斑病变 脉络膜新生血管 新生血管形成 玻璃膜疣 单侧 治疗组 视力丧失 医疗中心 临床试验 

分 类 号：R774.5[医药卫生—眼科] R774.1[医药卫生—临床医学]