维替泊芬联合玻璃体腔内注射曲安西龙治疗年龄相关性黄斑变性引起的所有类型的脉络膜新生血管  

Verteporfin therapy combined with intravitreal triamcinolone in all types of choroidal neovascularization due to age-related macular degeneration

作　　者：Augustin A.J. Schmidt-Erfurth U. 王静波 

机构地区：[1]Department of Ophthalmology, Klinikum Karlsruhe, Moltkestrasse 90, 76133 Karlsruhe, Germany Dr.

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第5期49-50,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Objective: To evaluate the efficacy and safety of photodynamic therapy with verteporfin combined with intravitreal triamcinolone in choroidal neovascularization secondary to agerelated macular degeneration (AMD). Design: Prospective, noncomparative, interventional case series. Participants: One hundred eighty-four patients undergoing treatment for neovascular AMD at one retinal referral center. Methods: One hundred eighty-four eyes of 184 consecutive patients (63.6%female, 36.4%male) with a mean age of 76.5 years and a follow-up of a median of 38.8 weeks (range, 12-103) were included in a case series. One hundred forty-eight (80.4%) patients had subfoveal choroidal neovascularization, 19 patients (10.3%) had juxtafoveal choroidal neovascularization, and 17 patients (9.2%) had extrafoveal choroidal neovascularization. Verteporfin photodynamic therapy was performed using the recommended standard procedure. A solution containing 25 mg of triamcinolone was injected intravitreally 16 hours after photodynamic therapy in 184 patients. The combined therapy procedure was repeated at the 3-month follow-up visits whenever persistent choroidal neovascularization leakage was documented angiographically. Main Outcome Measures: Mean change in best-refracted visual acuity (VA) between baseline and the last visit, and number of treatments necessary to achieve absence of leakage. Results: Visual acuity improved in the majority of patients (baseline VA, mean 20/125) by a mean increase of 1.22 Snellen lines and 1.43 lines using laser interferometry (P< 0.01). The mean number of required treatments was 1.21. Twenty-three eyes (12.5%) required 2 treatments, 6 eyes (3.26%) required 3 treatments, and 1 eye (0.5%) required 4 treatments. The combination treatment including laser and intravitreal steroid administration was well tolerated. Forty-six patients (25%) required glaucoma therapy due to a transient steroid-induced intraocular pressure (IOP) increase. Twelve patients (6.5%)were on topical medication for preexisting glaucoma. Two paObjective： To evaluate the efficacy and safety of photodynamic therapy with verteporfin combined with intravitreal triamcinolone in choroidal neovascularization secondary to agerelated macular degeneration （AMD）. Design： Prospective, noncomparative, interventional case series. Participants： One hundred eighty-four patients undergoing treatment for neovascular AMD at one retinal referral center. Methods： One hundred eighty-four eyes of 184 consecutive patients （63.6% female, 36. 4% male） with a mean age of 76.5 years and a follow-up of a median of 38.8 weeks （range, 12 - 103） were included in a case series, One hundred forty-eight （80. 4% ） patients had subfoveal choroidal neovascularization, 19 patients （10. 3% ） had juxtafoveal choroidal neovascularization, and 17 patients （9.2%） had extrafoveal choroidal neovascularization. Verteporfin photodynamic therapy was performed using the recommended standard procedure. A solution containing 25 mg of triamcinolone was injected intravitreally 16 hours after photodynamic therapy in 184 patientg The combined therapy procedure was repeated at the 3- month follow-up visits whenever persistent choroidal neovascularization leakage was documented angiographically. Main Outcome Measures： Mean change in best-refracted visual acuity （VA） between baseline and the last visit, and number of treatments riecessary to achieve absence of leakage.

关 键 词：中心凹下脉络膜新生血管 年龄相关性黄斑变性 玻璃体腔内注射 治疗中心 曲安西龙 维替泊芬 联合 光动力疗法 平均年龄 随访观察 

分 类 号：R773.4[医药卫生—眼科] R774.5[医药卫生—临床医学]