小细胞肺癌患者血清血管内皮生长因子含量水平的临床意义  

The clinical significance of serum vascular endothelial growth factor in small cell lung cancer

作　　者：王水利[1] 王茁[1] 罗小峰[1] 吴桦[1] 王宏涛[1] 孙刚[1] 韩雪芳[1] 

机构地区：[1]陕西省人民医院呼吸内科,陕西西安710068

出　　处：《现代肿瘤医学》2006年第7期810-812,共3页Journal of Modern Oncology

基　　金：陕西省自然科学基金资助项目(编号:2002C275)

摘　　要：目的探讨小细胞肺癌(SCLC)患者血清血管内皮生长因子(sVEGF)水平的临床意义。方法用酶联免疫吸附法(ELISA)测定45例SCLC患者、30例肺炎及50例健康人sVEGF的含量,并分析了sVEGF与患者临床分期、淋巴结及远处转移、化疗效果及化疗前后关系。结果SCLC组sVEGF水平(325.21±45.22μg/ml)明显高于对照组(175.18±60.56μg/ml,P<0.001)及肺炎组(182.29±45.22μg/ml,P<0.01),Ⅰ、Ⅱ期SCLC患者sVEGF水平(328.38±35.21μg/ml)低于Ⅲ、Ⅳ期(379.12±61.51μg/ml,P<0.005);与无转移者比较,淋巴结及远处转移者具较高的sVEGF水平(368.54±44.27μg/ml,P<0.001;376.21±21.52μg/ml,P<0.001)。29例患者治疗3个月后sVEGF水平下降(258.23±31.53μg/ml,P<0.001),但当肿瘤复发时sVEGF升高。结论SCLC者sVEGF变化与肿瘤转移、复发及预后等可能有关。Objective ：To study the clinical significance of serum vascular endothelial growth factor（sVEGF） in small cell lung cancer （ SCLC ）. Methods： sVEGF level was detected by enzyme - linked immunosorbent assay （ELISA）. The relationship between sVEGF level and clinical stage,node metastasis, distant metastasis, chemotherapeutic effect was analyzed. Results： sVEGF level in SCLCs was higher than that of patients with pneumonia （P 〈 0.01 ）and healthy controls （P 〈 0.001 ）. sVEGF level in SCLCs with stages Ⅲ and Ⅳ was higher than that of stages Ⅰ and Ⅱ （ P 〈 0. 005 ）. sVEGF level in patients who had node metastasis and distant metastasis was higher than that of no metastasis, sVEGF level in SCLCs decreased significantly after chemotherapy（ P 〈0.001 ） ,but it increased after tumor recurrence. Conclusion： sVEGF level in SCLCs may related to tumor recurrence, metastasis and prognosis.

关 键 词：小细胞肺癌 血清血管内皮生长因子 临床意义 

分 类 号：R734.2[医药卫生—肿瘤]