电化学治疗联合肝动脉插管置泵化疗治疗中晚期肝癌75例疗效观察  

Clinical report of 75 cases of advanced hepatic carcinoma treated by electrochemical therapy and intermittent hepatic arterial infusion chemotherapy

作　　者：代伟 丁超 权宽宏[2] 

机构地区：[1]西安唐城医院,胸外·肿瘤外科,陕西西安710016 [2]陕西省第二人民医院,陕西西安710005

出　　处：《现代肿瘤医学》2006年第7期852-854,共3页Journal of Modern Oncology

摘　　要：目的：探讨电化学治疗（electrochemical therapy，ECHT）联合肝动脉化疗治疗中晚期肝癌的疗效。方法：经开腹在直视下将特制的正负电极插入瘤体，通过电化学治疗仪将直流电施加于肿瘤，利用其产生的电离、电渗析作用，改变肿瘤组织生存的内环境，使肿瘤细胞代谢紊乱，发生变性、坏死，而达到治疗目的。治疗中局部可注入带正电荷的平阳霉素与高渗氯化钠溶液，以加速电化学反应，提高治疗效果。结果：全组75例均为Ⅲ期，术后恢复良好，随访6个月-5年，1，2，3年生存率分别为85%,76.6%,73.5%，4例生存期已超过5年。结论；电化学治疗肝癌疗效确切；创伤小，方法简便、安全性高、痛苦小、出血少，可避免肝叶切除术后所致的切面渗血，瘤体破裂及胆瘘等问题；不需阻断肝血流，可减少术后肝功能不全的发生。采用多电极合理设置的电化学治疗，并辅以肝动脉插管留置药泵周期性化疗，可提高疗效。Objective： To explore the efficacy of electrochemical therapy （ECHT） in the treatment of advanced hepatic carcinoma. Methods： All patients were treated by both EChT and hepatic arterial infusion chemotherapy. Results： All patients were followed -up from 6 months to 5 years. The survival rate of 1, 2, 3 year were 85%, 76. 6%, 73.5% respectively, 4 cases have survived for 5 years. Conclusion： EChT is an effective treatment for hepatic carcinoma, safe and simple in operation and less painful; can avoid bleeding, tumor rapture and biliary fistula; EChT can reduce hepatic failure which will result in the stop of blood circulation.

关 键 词：电化学 肝动脉插管置泵化疗 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]