促红细胞生成受体在上皮性卵巢肿瘤中的表达及其意义  

Expression of erythropoietin receptor (EpoR) in ovarian epithelial tumor

作　　者：王美娟[1] 于莲君[1] 李连香[1] 

机构地区：[1]陕西省人民医院,陕西西安710068

出　　处：《现代肿瘤医学》2006年第7期878-879,共2页Journal of Modern Oncology

摘　　要：目的：了解促红细胞生成受体（EpoR）在卵巢良性、交界性、恶性上皮性肿瘤组织中的表达，探讨其与上皮性卵巢癌肿瘤发生发展的关系。方法：用免疫组化SP法对51例卵巢癌组织、25例交界性上皮性卵巢肿瘤、31例良性上皮性卵巢肿瘤组织中EpoR的表达情况进行了检测。结果：EpoR在恶性及交界性上皮性卵巢肿瘤中的强阳性表达率分别为67％、48％，明显高于良性肿瘤组的32％（P〈0．05）。在卵巢癌中EpoR的表达与卵巢癌的临床分期有关，Ⅲ～Ⅳ期卵巢癌强阳性表达率73％，明显高于Ⅰ～Ⅱ期的56％（P〈0．05），而与细胞分化程度无明显关联。但有淋巴结转移的病例强阳性表达率76％，明显高于无淋巴结的58％。结论：EpoR的表达与上皮性卵巢肿瘤的发生发展关系密切。Objective：To investigate the expression of erythropoietin receptor（EpoR） in ovarian epithelial tumor. Methods： The expression of EpoR was detected in malignant, borderline and benign ovarian tissues by immunohistochemical SP method. Results： Intense expression rates of EpoR in malignant, borderline, benign epithelial tumor tissues of ovary were 67%, 48%, 32% respectively. There were a significant difference between malignant, borderline and benign tumors （P 〈 0.05 ） . In ovarian cancer, the expression of EpoR had a significant rehvance to clinical phase but no relevance to pathological grades. The intense expression rate （73%） in phase Ⅲ -Ⅳ of ovarian cancer was much higher than that in phase Ⅰ-Ⅱ （56%） . The intense expression rate （76%） in lymph node metastasis group was much higher than that in no lymph node metastasis group （58%）. Conclusion： EpoR is related to the tumorigenesis and progress of the ovarian cancer.

关 键 词：促红细胞生成素受体 免疫组化 卵巢肿瘤 

分 类 号：R737.31[医药卫生—肿瘤]