Fas基因A-670G单核苷酸多态性与阿尔茨海默病的相关性分析  

The Correlation between A-670G Polymorphism in Fas Gene and Alzheimer Disease

作　　者：何小明[1] 张振馨[1] 张俊武[2] 周涌涛[1] 唐牟尼[3] 武成斌[4] 洪震[5] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院神经科,北京100730 [2]中国医学科学院中国协和医科大学基础医学研究所医学分子生物学实验室,北京100730 [3]广州市精神病医院老年科,广东广州510370 [4]西安交通大学第一医院神经内科,陕西西安710061 [5]上海复旦大学附属华山医院神经内科,上海200040

出　　处：《中国神经免疫学和神经病学杂志》2006年第4期197-200,共4页Chinese Journal of Neuroimmunology and Neurology

基　　金：国家"九五"攻关课题基金资助项目(96-096-05-01);美国中华医学基金会国际合作基金资助项目(99-699)

摘　　要：目的探讨中国汉族人群中Fas基因A-670G单核苷酸多态性(SNP)与阿尔茨海默病(AD)的相互关系。方法采用等位基因特异性PCR(A-S PCR)技术检测509例AD患者和561名健康对照者Fas基因A-670G位点SNP的分布,并分析各基因型与发病年龄和疾病严重程度的关系。结果AD组和对照组基因型频率(χ2=0.66,P>0.05)及等位基因频率(χ2=0.70,P>0.05)差异均无统计学意义。进一步将样本按发病年龄和性别分层其差异也未发现统计学意义(P>0.05)。而且,各基因型与发病年龄、疾病严重程度也不相关。结论中国汉族人群中Fas基因A-670G位点SNP与AD无关联。Objective To evaluate the correlation of A-670G single nucleotide polymorphism （SNP） in Fas gene with Alzheimer disease （AD） in Chinese Han population. Methods A-670G SNP in Fas gene was detected by Allele-Specific PCR （A-S PCR） technique in 509 patients with AD and 561 healthy controls. Results The current study did not demonstrate any significant difference in A-670G Fas genotype （X^2 = 0. 66, P〉0.05） or allele frequencies （X^2 = 0. 70, P〉0. 05） between AD patients and controls. When AD and control groups were stratified by age/age at onset and sex, no significant difference was observed in age/age at onset subsets or in gender subsets （P 〉 0. 05）. Our data also showed no significant difference of the correlation between the genotypes and the severity of the disease. One-Way ANOVA showed that Fas genotype had no effect on the age of onset for developing AD. Conclusions Our results indicate that A-670G SNP in Fas gene is not associated with AD.

关 键 词：阿尔茨海默病 FAS基因 等位基因特异性PCR 单核苷酸多态性 

分 类 号：R749.16[医药卫生—神经病学与精神病学]