亚低温对急性脑卒中患者血清IL-2、IL-6、TNF-α水平的影响和临床意义  

Effects of Mild Hypothermia on the Serum IL-2,IL-6,TNF-α Levels in Patients with Acute Stroke and Its Clinical Significance

作　　者：董少军[1] 吴承志[1] 刘培明[1] 魏芳[1] 王靖东[1] 吕晓侠[1] 马锐[1] 许希海[1] 

机构地区：[1]安徽省淮北矿工总医院神经内科,安徽淮北235000

出　　处：《中国神经免疫学和神经病学杂志》2006年第4期238-239,252,共3页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的 探讨亚低温对急性脑卒中患者血清IL-2、IL-6、TNF-α的影响和临床意义。方法 将36例急性脑卒中患者随机分为亚低温和常规治疗组．检测入院第1天（d1）、第3～5天（d3～5）、第14天（d14）血清IL-2、IL-6、TNF-α水平并进行对照比较。结果 两组患者d1、d3～5、d14血清IL-2、IL-6、TNF-α水平均高于正常组（P〈0．05）,亚低温组出d3-5、d14血清IL-2、IL-6、TNF-α水平低于同期常规治疗组（P〈0．05）。结论 亚低温可降低急性脑卒中患者血清IL-2、IL-6、TNF-α水平．抑制脑卒中后炎症反应．保护脑神经细胞。Objective To explore the effect of mild hypothermia on serum levels of IL-2, IL-6 and TNF-α as well as its clinical significance. Methods Thirty-six patients with acute stroke were divided into two groups treated by mild hypothermia and routine therapy respectively. The serum levels of IL-2, IL-6, TNF-α on the first （d1）, third-fifth（d3-5 ） and, fourteenth（d14 ）day after hospitalization were monitored and analyzed comparatively between the two groups. Results The serum levels of IL-2, IL-6, TNF-α of both groups on d1, d3-5, d14 were all higher than those of the normal group（P〈0. 05）. The serum levels of IL-2, IL-6,TNF-α in patients treated with mild hypothermia on d3-5 d14 were lower than those in routine group （P〈 0.05）. Conclusions Mild hypothermia treatment could decrease the serum levels of IL-2, IL-6, TNF-α in patients with acute stroke and inhibit the inflammatory reaction so as to protect the cerebral neurons.

关 键 词：急性脑卒中 低温 生物因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]