胃肠道类癌中生长抑素和p21^(WAF1/CIP1)蛋白表达的意义  

Significance of somatostatin and p21^(WAF1/CIP1) protein expression in gastrointestinal carcinoid

作　　者：林岩[1] 王显艳[1] 张静艳[1] 温秋婷[1] 赵坤[1] 刘微[1] 戚基萍[2] 

机构地区：[1]齐齐哈尔医学院病理教研室,齐齐哈尔161042 [2]哈尔滨医科大学第一临床医学院病理科,哈尔滨150001

出　　处：《中国肿瘤临床与康复》2006年第3期205-207,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：黑龙江省教育厅科技基金项目(10541271)

摘　　要：目的探讨生长抑素和p21WAF1/C IP1蛋白阳性表达与胃肠道类癌的组织分化、浸润和转移的关系。方法采用免疫组化S-P法对36例胃肠道类癌组织生长抑素和p21WAF1/C IP1蛋白的表达进行检测。结果36例类癌组织中,生长抑素和p21WAF1/C IP1蛋白较多表达于高分化类癌组(P<0.05),随着肿瘤的浸润和淋巴结转移,生长抑素阳性表达率显著降低(P<0.01),p21WAF1/C IP1阳性表达差异有显著性(P<0.05)。结论生长抑素和p21WAF1/C IP1低表达在类癌的组织分化和发展中起着重要作用,可用于临床对患者进行预后判断。Objective To study the relationship between the expression of somatostatin and p21^WAF1/CIP1 protein and biological behavior of gastrointestinal carcinoid. Methods The immunohistochemistry S-P method was adopted to examine the expression of somatostatin and p21^WAF1/CIP1 protein in thirty-six cases of gastrointestinal eareinoid. Results In thirty-six eases of gastrointestinal eareinoid, somatostatin and p21^WAF1/CIP1 protein were mostly expressed in typical eareinoid （ P 〈 0.05 ）. The positive rates of somatostatin - decreased significantly （P 〈0.01 ） and the expression of p21^WAF1/CIP1 Was correlated with the invasion and metastasis of eareinoid （ P 〈 0.05）. Conclusion The low expression of somatostatin and p21^WAF1/CIP1 Protein might play a great role in the differentiation and development of gastrointestinal earcinoid, and can be used for prognostic judgement.

关 键 词：类癌 生长抑素 P21^WAF1/CIP1 免疫组织化学 

分 类 号：R735[医药卫生—肿瘤]