原发性肝癌甲胎蛋白阳性与乙肝病毒标志物感染血清学的关系  

Serological relationship between primary hepatocellular carcinoma with positive alpha fetoprotein and hepatitis B virus infection

作　　者：王鲁华[1] 方琳丽[1] 麦芒[1] 关楚文[1] 欧阳亮[1] 

机构地区：[1]汕头大学医学院第一附属医院核医学科,广东省515041

出　　处：《实用诊断与治疗杂志》2006年第7期487-489,共3页Journal of Practical Diagnosis and Therapy

摘　　要：目的:探讨原发性肝癌患者血清甲胎蛋白阳性与乙型肝炎病毒感染发生的关系。方法:采用化学发光免疫分析和EL ISA法分别检测90例原发性肝癌患者、40例健康对照组进行了血清甲胎蛋白、乙型肝炎病毒血清五项标志物检测。结果:90例原发性肝癌患者中有87例乙肝五项标志阳性,乙型肝炎病毒总感染率为96.7%。乙型肝炎病毒总出现率:HB sA g(十)为92.2%,HB eA g(十)为17.8%,HB sA b(十)为4.4%,HB eA b(十)为57.8%,HB cA b(十)为65.5%;5项指标全为阴性者占3.3%,明显高于健康对照组47.5%(19/40)(P<0.01)和乙型肝炎病毒总感染率(52.5%)(P<0.01)。肝癌组乙型肝炎病毒血清标志物感染模式,以HB sA g、抗-HB e和抗-HBC阳性模式多见,为40%。表明该模式的乙肝患者为原发性肝癌的高危人群。结论:乙型肝炎病毒与原发性肝癌之间的关系非常明确,乙型肝炎病毒感染不仅是肝癌发生的一个重要的危险因素,而且表明肝癌患者常伴有乙型肝炎病毒的复制活跃。因此,积极预防和控制乙型肝炎病毒感染流行,是减少原发性肝癌发生的关键所在。Objective To explore the relationship between primary hepatocellular carcinoma patients with positive alpha fetoprotein and hepatitis B virus infection. Methods Blood serum alpha fetoprotein and five hepatitis B virus markers from 90 primary hepatocellular carcinoma patients and 40 healthy controls were separately detected with chemiluminescence immunoassay and ELISA. Results Of the 90 primary hepatocellular carcinoma patients, 87 had the positive five hepatitis B virus markers, the total hepatitis B virus infection was 96.7%. HBsAg（＋） was 92.2%, HBeAg（-＋） was 17. 8%, HBsAb（＋） was 4.4%, HBeAb（＋） was 57.8%, HBcAb（＋） was 65.5 %, and total five hepatitis B virus markers were negative for 3.3 %, which was apparently much higher than the those in controls（47.5%） （P〈0.01） and the total positive rate of hepatitis B virus of the healthy controls （52. 5%） （P 〈 0. 01）. The infection models of hepatitis B virus serum marker in primary hepatocellular carcinoma patients was mostly HBsAg, anti-HBe, and anti-HBC positive models, which accounted for 40%. It was indicated that hepatitis B patients of this model were the highly dangerous crowd of primary hepatocellular carcinoma. Conclusion The relationship between hepatitis B virus and primary hepatocellular carcinoma is very definite. Hepatitis B virus infection is an important danger factor in the occurrence of primary hepatocellular carcinoma, and it also indicates that primary hepatocellular carcinoma patients are often accompanied by active hepatitis B virus replication. Therefore, the key point to reduce primary hepatocellular carcinoma is to prevent and control hepatitis B virus epidemic infection actively.

关 键 词：原发性肝癌 甲胎蛋白 乙型肝炎病毒 

分 类 号：R735.7[医药卫生—肿瘤]