解偶联蛋白与动物的能量代谢  

Uncoupling Proteins and Energy Metabolism in Animals

作　　者：刘丽[1] 田建云 李琦华[1] 贾俊静[1] 余红心[1] Mark Jois Graham H McDowell 

机构地区：[1]云南农业大学云南省动物营养与饲料重点实验室,云南昆明650201 [2]德宏州潞西市畜牧局兽医工作站,云南潞西678400 [3]澳大利亚拉筹伯大学

出　　处：《云南农业大学学报》2006年第4期504-510,共7页Journal of Yunnan Agricultural University

基　　金：云南省科技厅自然基金项目资助(2003C0048M);云南省动物营养与饲料重点实验室开放基金

摘　　要：动物需要能量来维持生命活动,所需的能量主要来源于食物里的碳水化合物、脂肪和蛋白质。即使在体重平衡(非生产、生长状态)动物仍需要能量来维持体重、体温恒定及肌肉的基本活动。最新发现的线粒体内膜转运蛋白质,具有调节能量代谢的作用,它们的活动增加了动物的基础代谢率,这类蛋白质被称为解偶联蛋白(Uncoup ling Prote ins,UCPs)。UCPs作为质子通道驱散氧化呼吸时形成的H+梯度,降低了线粒体膜电位差ΔμH+,从而增加呼吸产热,阻止ATP的形成。目前已至少发现有5种UCPs(UCP1,UCP2,UCP3,UCP4和UCP5),这个家族的蛋白质已经在人类、哺乳动物、禽类、鱼、真菌、甚至在植物不同组织的线粒体内膜上被发现。Animals require energy to support requirements for maintenances life activity. The animal derives energy by partial or complete oxidation of carbohydrates, fats and proteins ingested. Even in non-productive states, animals need energy for sustaining the body, keeping a stable body temperature, and for maintaining muscular activity. Located in the inner membrane of mitochondria, uncoupling proteins （UCPs） form a family of mitochondrial anion transporters affect energy metabolism and their activity increase basal metabolic rate because UCPs can act as leaks in mitochondrial inner mem- branes allowing protons to leak into the matrix thus dissipating the proton gradient during electron transport chain, uncoupling respiration from ATP production and allowing the dissipating of heat. Up to now, there have been identified five UCPs （UCP1 ,UCP2 ,UCP3 ,UCP4 and UCPS）family members in inner membrane of mitochondria including in human, mammals, birds, fish, fungi and even in plants.

关 键 词：解偶联蛋白 能量代谢 基础代谢率 氧化磷酸化作用 

分 类 号：S852.2[农业科学—基础兽医学]