Indian hedgehog在宫颈癌及其癌前病变早期诊断中的意义  

The significance of Indian hedgehog in the early diagnosis of cervical malignant neoplasms and their precursors

作　　者：玄延花[1] 任香善[1] 刘双平[1] 

机构地区：[1]延边大学基础医学院病理学与法医学教研部,吉林延吉133000

出　　处：《延边大学医学学报》2006年第2期86-88,共3页Journal of Medical Science Yanbian University

摘　　要：[目的]探讨Indian hedgehog(IHH)过度表达在早期发现宫颈癌及其癌前病变中的病理学意义.[方法]采用免疫组织化学染色方法对37例宫颈浸润型鳞状上皮癌、37例宫颈上皮内新生物(CIN)及32例非肿瘤性宫颈病变标本进行IHH蛋白表达情况的检测.[结果]13例宫颈浸润型鳞状上皮癌、7例CINⅢ病变及2例CINⅡ病变标本中IHH特异性地表达在癌细胞和不典型增生细胞胞浆中.[结论]IHH的过度表达是早期诊断宫颈癌及其癌前病变的有效指标.OBJECTIVE To evaluate the diagnostic value of Indian hedgehog（IHH） in the cervical epithelial malignant neoplasms and their precursor. METHODS The immunostaining was done using IHH polyclonal antibody in 37 of invasive squamous cell carcinomas, 37 of cervical intraepithelial neoplasia, and 32 of non-neoplastic cervices. RESULTS IHH was specifically detected in 13 cases of squamous cell carcinoma, 7 cases of CIN Ⅲ , and 2 cases of CIN Ⅱ . CONCLUSION The overexpression of IHH was a useful marker for the diagnosis of epithelial neoplasms and their precursors of cervix uteri.

关 键 词：子宫颈肿瘤 基因 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤] R780.2[医药卫生—临床医学]