SARS冠状病毒抗体2年追踪研究  

2 YEARS FOLLOW UP STUDY OF ANTIBODY TO SARS-COV

作　　者：吴立平[1] 田相义[1] 常一华[1] 郑蕾[1] 张莉媛[1] 王乃昌[1] 那丹宇[1] 张秋香[1] 马建瑞[1] 赵习芳[1] 

机构地区：[1]山西省疾病预防控制中心,太原030012

出　　处：《现代预防医学》2006年第7期1075-1076,1079,共3页Modern Preventive Medicine

基　　金：山西省科技攻关项目(032001)

摘　　要：目的：探讨SAPS-CoVIgG在人体内的持续时间。方法：对发病后不同时间采集的176例临床诊断病例的血清标本；采用北京华大GBI生物技术有限公司生产的间接ELISA试剂，进行SARS-CoVIgG抗体的检测，结果：在发病后的0-7d、8-14d、15-21d、31～60d内，SARS-CoVIgG的累计阳性率分别为11．80％、38．46％、77．27％、22-30d升至91．67％，然后进入平台期；在3个月时，抗体阳性率达到100％，一年时仍维持在93．88％，到两年时，阳性率下降为88．89％。SARS IgG的OD值随时间升高的速度慢于阳性率，在90～120d与阳性率的峰值吻合，半年以后开始下降，到1年和2年时，抗体的滴度下降了22％和40％。结论：SARS-CoVIgG可维持2年以上，但已呈下降趋势。Objective： To figure out the persistent time of IgG antitibody to SARS-CoV in SARS cases. Methods： The IgG antitbodies to SARS- CoV were tested by indirect ELISA in sera samples of 176 confirmed SARS cases. Results During days of 0 - 7, 8 - 14, 15 -21, after symptoms onset, the cumulated positive rate of SARS-CoV IgG was 11.76%, 38.46%, 77.27% respectively. In 22-30 days, the cumulated positive rate reaches 91.67%, then kept at the level above 90% until the third months when positive rate is 100%. The cumulated positive rate of SARS-CoV IgG in 1 year was declined to 93.88%, but 88.89% of SARS cases was still kept positive IgG antitbodies to SARS- CoV after 2 years. The increasing speed of optical density value of SARS - CoV IgG was slower than that of cumulated positive rate of SARS - CoV IgG. The curve of optical density value was intersected with the peak of the curve of positive rate during 90-120d, then declined by 22% from 6 months and declined by 40% in 1 and 2 years.Conclusion： The IgG antibodies to SARS- CoV can be maintained for more than 2 years wheile the decreasing trend of titer for SARS-CoV IgG occur.

关 键 词：SARS-COV SARS-CoVIgG 追踪观察 

分 类 号：R373.1[医药卫生—病原生物学]