心肌多肽抗疲劳效应的实验研究  

EXPERIMENTAL STUDY ON ANTI-FATIGUE EFFECT AND ANTI-OXIDATIVE CAPABILITY OF CARDIAC POLYPEPTIDES

作　　者：李茂辉[1] 叶丽杰[1] 卢桂华[2] 赵卓夫 江宁[3] 徐立民[3] 

机构地区：[1]沈阳医学院预防医学系卫生化学教研室,沈阳110034 [2]辽宁省疾病预防控制中心 [3]沈阳海汇天成生物科技有限公司

出　　处：《现代预防医学》2006年第7期1097-1099,共3页Modern Preventive Medicine

摘　　要：目的:通过实验研究心肌多肽提高小鼠抗疲劳作用和耐缺氧能力和探讨可能的生物机制。方法:采用昆明种小鼠,分低、中、高剂量组,经口灌胃给予心肌多肽30 d,剂量分别为0.5 g/kg/d,1.0 g/kg/d,2 g/kg/d,另设蒸馏水对照组。观察小鼠负重游泳时间,耐缺氧能力,并测定抗疲劳相关生化指标:血乳酸、血中尿素氮含量、肝糖原含量以及血红细胞和肝脏中的超氧化物歧化酶(SOD)活力。结果:心肌多肽的中、高剂量组均能延长小鼠负重游泳时间以及耐缺氧能力。并且小鼠运动后血乳酸、血中尿素氮含量与对照组相比明显降低,肝糖原含量明显高于对照组,并且小鼠的血红细胞和肝脏中的超氧化物歧化酶(SOD)活力明显高于对照组。结论:心肌多肽具有增强小鼠抗疲劳和耐缺氧的能力。Objective： To study and discuss the anti - fatigue effects and biological mechanism of cardiac polypeptides. Methods： Cardiac polypeptides was administered to mice in treated group for 30 days by 0.5 g/kg/d, 1.0 g/kg/d, 2.0 g/kg/d respectively, and the changes of exhaustive swimming time and the bear anoxia ability were measured. Then biochemical index were measured which includes blood lactic acid, urea nitrogen, liver glycogen and the activities of superoxide dismutase （SOD） of Hb and liver in the mice. Results： Compared with control group, the exhaustive swimming time and bear anoxia ability of the administered mice in treated group were significantly longer, while the SOD activities of Hb and live in mice obviously increased. And the content of hepatic glycogen increased obviously while the content of blood lactate, and blood urea nitrogen decreased significantly. Conclusion： The cardiac polypeptides have a potential anti - fatigue effect and anti - oxidative capability.

关 键 词：心肌多肽 抗疲劳 生物机制 小鼠 

分 类 号：R285.5[医药卫生—中药学] R392.12[医药卫生—中医学]