吸入米力农对实验性充血性心力衰竭大鼠血流动力学指标的影响  

Effect of milrinon inhalation treatment on hemodynamics changes of CHF rats

作　　者：尹宁[1] 杨映红[1] 邵东华[1] 吕德生[1] 王洪[1] 

机构地区：[1]江苏大学附属人民医院麻醉科,江苏镇江212002

出　　处：《江苏大学学报（医学版）》2006年第3期207-209,共3页Journal of Jiangsu University：Medicine Edition

基　　金：江苏省科技厅社会发展计划基金(BS2006035)

摘　　要：目的：研究心力衰竭（CHF）大鼠吸入磷酸二酯酶Ⅲ抑制剂——米力农后血流动力学指标变化。方法：设充血性心力衰竭（CHF）组：雄性sD大鼠24只（100±8）g，在第二、三肋间开胸，用1mm肽夹钳夹主动脉，造成主动脉缩窄，8～10周后，造成CHF，大鼠至（350±10）g，随机分为①吸入NaCI3min，②吸入米力农（1mg／m1）3min后予第二次开胸。正常对照组：雄性SD大鼠24只（350±10）g，随机分为①吸入NaCI3min，②吸入米力农（1ms／m1）3min。两组大鼠均予颈动、静脉置管，开胸后分别给予肺动脉和左房置管，分别测量平均动脉压（MAP）、肺动脉压（PAP）、左房压（LAP）、中心静脉压（CVP）和心排出量（CO），并计算肺血管阻力（PVR）、外周血管阻力（SVR）、总血管阻力（TVR）、PVR／SVR，测量血气和称量肺干湿重比（W／D）和心脏重量和体重比（HW／BW）。结果：①CHF大鼠吸NaCI前后PVR／SVR无明显改变；②CHF大鼠吸米力农前后PVR／SVR明显下降，P＜0．05；③对照组吸米力农前后PVR／SVR无明显改变；④CHF大鼠HW／BW明显高于正常对照组大鼠，P＜0．05；CHF大鼠肺W／D明显高于正常对照组大鼠，P＜0．05。结论：米力农吸入治疗明显降低CHF大鼠PVR／SVR，吸入治疗不改变体循环血压而降低肺动脉压，这种方法可作为新的治疗CHF的方法用于临床。Objective： To study changes in hemodynamics of milrinon inhalation treatment congestive heart failure（CHF） rats. Methods： CHF rats group： male 24 SD rats（ 100 ± 8 ） g, bw, in the first open chest operation first open chest operation supracoronary aortic banding with titanium clip was giving, progressive development of CHF over 8 - 10 weeks, the rats weight arrived （350 ± 10）g; In the second operation, put the catheter in pulmonary artery and left atrium,randomly divided two groups with each group 12 rats： group 1 inhalation NaC1,3 rain, group 2 inhalation milrinone （ 1 mg/ml） ,3 rain. Control group ： normal male 24 SD rats （350 ±10）g,bw, randomly divided two groups, group 1 inhalation NaC1,3 rain, group 2. inha- lation milrinone（ 1 mg/ml） ,3 rain,and were put the catheter into pulmonary artery and left atrium too. Both groups we measured MAP, PAP, LAP, CVP CO and calculated PVR, SVR, TVR, PVR/SVR. We meas- ured blood gas and calculated the ratio of wet/dry lung weight（W/D） ,the ratio of heart/body weight（ HW/ BW）. Results： ①In CHF rats before and after inhalation NaC1 the ratio PVR/SVR had no significant change ; ②In CHF rats before and after inhalation mirinone the ratio PVR/SVR had significant decrease, P 〈0. 05 ;③ In control group rats before and after inhalation mirinone the ratio PVR/SVR had no significant change ; ④In CHF rats the ratio of HW/BW was significantly increased P 〈0. 05, and the ratio of lung W/ D was significantly increased too, P 〈0. 05. Conclusion ： Milrinon inhalation treatment decreased the ratioPVR/SVR in CHF. this treatment was a new trials to treating pulmonary venous hypertension.

关 键 词：充血性心力衰竭 米力农 大鼠 吸入治疗 血流动力学指标 

分 类 号：R-33[医药卫生]