超选择动脉内多种药物灌注介入治疗急性脑梗死  

Interventional therapy for acute brain infarction via superselective intra-arterial infusion of several thrombolytic drugs

作　　者：朱军[1] 宋纯玉[1] 王加利[1] 刁兴涛[1] 王全相[1] 

机构地区：[1]山东省莱芜市人民医院神经外科,莱芜271100

出　　处：《上海医药》2006年第7期320-322,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:通过对8例急性脑梗死介入溶栓治疗分析,就多种药物注入剂量、速度、治疗时机及相关并发症进行讨论。方法:经超选择性动脉内插管灌注尿激酶、血栓通、地塞米松等多种药物溶栓,血管造影证实阻塞血管开通情况。结果:阻塞血管完全再通2例,部分再通4例,开通率75%,未开通2例;临床治愈3例,显效3例,有效2例。结论:多种药物灌注介入性溶栓方法是治疗急性脑梗死的一种安全有效的方法。介入溶栓时机越早越好。在限定的时间窗内,控制溶栓药注入剂量和速度的条件下,可取得比较满意的疗效,并不增加出血性并发症的发生率。Objective： To evaluate the clinical efficacy and safety of interventional thrombolysis therapy via superseleetive intra - arterial catheterization in the treatment of acute cerebral infarction and discuss drug dosage, infusion speed, treatment time, and related complications. Methods： Eight patients with acute cerebral infarction were infused with several kinds of thrombolytie drugs, such as urokinase, Xueshuantong, and dexamethasone, ere, via superseleetive intra- arterial catheterization within 24 h. Reeanalization of occluded vessels was observed by angiography, Results： Vessel recanalization was complete in 2 out of 8 patients and partial in 4 patients. The total reeanalization rate was 75%. It was absent in 2 patients. Three patients were cured. Three patients were substantially improved and 2 patients were partially improved. Gonclusion： Interventional therapy using several kinds of thrombolytie drugs is effective and safe in the treatment of acute eerebral infarction. Earlier therapy is asseeiated with better effects. Satisfactory effects ean be obtained by eontrelling the drug dosage and the infusion speed in the limited time windows without inereasing hemorrhage risk.

关 键 词：急性脑梗死 介入治疗 尿激酶 血栓通 

分 类 号：R743.33[医药卫生—神经病学与精神病学]