用ROC曲线分析血脂水平与非酒精性脂肪肝病的关系  

Analysis of the relationship between the blood lipid concentration and non-alcoholic fatty liver diseasa by ROC curve

作　　者：石柯[1] 袁伟建[2] 

机构地区：[1]中南大学湘雅医院干部医疗科,湖南长沙410008 [2]中南大学湘雅医院消化内科,湖南长沙410008

出　　处：《中国医学工程》2006年第3期259-261,269,共4页China Medical Engineering

摘　　要：目的分析血脂水平与非酒精性脂肪肝病(NAFLD)的关系。方法对健康体检人群(22￣55岁,平均48岁),进行体格检查、血脂水平[包括三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]和B超检测。确诊为脂肪肝者134例(男81例,女53例)设为观察组(简称脂肪肝组);排除脂肪肝、且血脂4项均在正常范围者89例(男39例,女50例)设为对照组,以上两组用ROC进行分析。结果两组之间血脂4项检查,t检验均有显著差别;而接收者工作特征曲线(ReceiverOp-eratingCharacteristicsCurve),简称ROC曲线下面积(AUC),TG、TC、HDL-C和LDL-C分别为0.934、0.845、0.290和0.756。结论甘油三脂(TG)对NAFLD的诊断意义较大,TC和LDL-C,HDL-C无诊断价值。[Objective] To analyze the relation between the blood lipid concentration and non-alcoholic fatty liver disease （NAFLD） by ROC curve. [Methods] B-ultrasonography by physical examination, blood lipid concentration assay [including TG （NV 0.52-1.56mmol/L）, TC （NV 2.8-5.6 mmol/L）, HDL-C （NV 0.88-1.76 mmol/ L） and LDL-C （NV 1.55-3.19 mmol/L）] examinated 223 adults of out-patient, department of our hospital aged from 22 to 55 （mean 48） who were divided to two groups, observe group ：134 case （male 81, female 53） were diagnosed as non-alcoholic lipid liver; control group ：89 peoples （male 39, female 50） with normal B-ultrasonography, physical and blood lipid concentration. The relationship between the blood lipid concentration and non-alcoholic fatty liver in two groups was compared, respectively. [Result] The significant differences were found in all four test items between two groups and AUC of ROC of TG, TC, HDL-C and LDL-C were respectively 0.934, 0.845, 0.290 and 0.756. [Conclusions] TG is a significant diagnosis assay for NAFLD, then TC and LDL-C.But HDL-C has no diagnosis value.

关 键 词：血脂 非酒精性脂肪肝病 接收者工作特征曲线 

分 类 号：R575.5[医药卫生—消化系统]