双相情感障碍发病因素及防治对策探讨  

To Explore the Pathogensis of Bipolar Disorder and Preevention Measures

作　　者：张毅宏[1] 张翔[1] 吴怀安[1] 段卫东[1] 

机构地区：[1]深圳市康宁医院,广东深圳518020

出　　处：《中国初级卫生保健》2006年第7期56-58,共3页Chinese Primary Health Care

摘　　要：目的探讨双相情感障碍发病因素。方法收集90名在我院住院的双相情感障碍患者作为观察组,同时,在本院职工中随机抽取90人作为对照组,采用病例对照研究方法,对两组研究对象进行家系调查、运用聚合酶链反应—限制性片段长度多态性方法,检测所有研究对象5-HT2A受体基因,T102C位点基因型以及对研究对象进行生活事件调查评定。结果家系调查结果显示:观察组亲属中患精神疾病的人数明显多于对照组,差异具有显著性(#2=23.62,P<0.01);分子遗传学分析结果显示:观察组和对照组5-HT2A受体基因多态性位点T102C基因型和等位基因频率差异无显著性(#2=1.133,P<0.05;#2=0,P=1);生活事件评定显示:观察组发病前一年左右的生活事件及严重程度均高于对照组,两组比较具有显著性差异。结论遗传因素和生活事件因素在双相情感障碍的发病机制中起重要的作用,但在中国汉族人群中,5-HT2A受体基因多态性位点T102C在双相情感障碍的发病机制中不起作用。因此,双相情感障碍的防治应从家庭、社区、社会入手,可以有效降低其发病率和复发率,促进患者回归社会。OBJECTIVE To explore the pathogensis of Bipolar Disorder. METHOD 90 Bipolar Disorder in-patients from our hospital were collected as an observation group and 90 employees in our hospital were randomly taken as a control groupo We studied all the sample＇ s families in both groups by using case-control methods, genotyped 5-HT2A receptor gene and T102C position gene types in our samples by using PCR-restriction fragment length method, and assessed all the sample＇ s life events which had happened about the year or so before the onset of the patients. RESULT family study results show that the number of the patient group relatives having mental disorders is more than that of control group which is significantly different between two groups （x^2=23.62, P〈0.01 ） ; molecular genetic analysis results show that no difference can be seen in the 5-HT2A receptor gene T102C polymorphism and frequency of alleles between two groups （x^2=1.133, P〈0.05;x^2=0, P=1）; life event assessments suggest that the life events of patient group had more frequency and severer extentthan that of control group which is significantly different. CONCLUSION Our results suggest that the genetic factors and life events play important roles in the pathogenesis of Bipolar Disorder, but the 5-HT2s receptor gene T102C polymorphism seems not to confer susceptibility to the pathogenesis of Bipolar Disorder among Chinese people. Hence, start to take measures to prevent and cure the Bipolar Disorder from family, community and society should be an effective way to reduce the incidence of the disease and its recrudescence and enable them return to society.

关 键 词：双相情感障碍 家系调查 分子遗传学 5-HT2A受体基因 生活事件 

分 类 号：R395.1[哲学宗教—心理学]