CYFRA21-1和CA-125联合检测在非小细胞肺癌诊断中的意义  

Clinical significance of tumor markers CYFRA21-1 and CA125 in non-small cell lung cancer

作　　者：姚群峰[1] 薛津若[1] 肖凌[1] 

机构地区：[1]湖北中医学院医学检验与技术系,武汉430030

出　　处：《公共卫生与预防医学》2006年第3期14-15,19,共3页Journal of Public Health and Preventive Medicine

基　　金：湖北省高等学校优秀中青年科技创新团队计划(T200607)资助

摘　　要：目的研究糖链抗原-125(CA-125)和细胞角蛋白19片段21-1(CYFRA 21-1)联合检测在非小细胞肺癌(N SCLC)诊断中的临床意义。方法采用放射免疫法检测了83例肺癌患者、28例肺部良性疾病患者及25名健康体检者的血清CA-125和CYFRA 21-1。结果肺癌组血清CA-125和CYFRA 21-1含量显著高于正常对照组和肺良性疾病组;CYFRA 21-1在肺鳞癌中表达水平最高,CA-125在肺腺癌中表达水平最高;CA-125和CYFRA 21-1联合检测肺癌的敏感性为83.9%,特异性为80%。结论联合检测CA-125和CYFRA 21-1对于临床诊断肺癌,特别是非小细胞肺癌(N SCLC)具有重要临床价值。Objective To study the clinical siginificance of tumor markers CYFRA21-1 and CA125 in non-small cell lung cancer. Methods The serum CYFRA21-1 and CA125 were measured in 83 cases of lung cancer,28 cases of benign pulmonary disease and 25 cases of normal control. Results The serum CYFRA21-1 and CA125 in patients with cancer were significantly higher than those in group with benign lung disease and the control ;Patients with squamous cell carcinoma of lung had a higher CYFRA21-1 level, while patients with adenocarnoa had a higher CA125 level. The sensitivity and specificity of the combined determination containing the two tumormarkres were 83.9% and 80% respectively. Conclusion The use of a combination of these three tumormarkers was recommended for the diagnosis of lung cancer.

关 键 词：肺肿瘤 肿瘤标志物 CA-125 CYFRA21-1 

分 类 号：R-33[医药卫生]