红霉素发酵培养基优化研究  

A research on the improvement of medium composition for erythromycin fermentation

作　　者：张金国[1] 刘翔[1] 

机构地区：[1]安阳工学院,安阳455000

出　　处：《中国抗生素杂志》2006年第7期406-407,416,共3页Chinese Journal of Antibiotics

基　　金：河南省2005年科技发展计划科技攻关项目(编号0524270053)

摘　　要：对红霉素发酵培养基进行了优化,选用A粉和B粉代替原工艺中的淀粉及部分葡萄糖和豆饼粉。采用正交试验设计方法,确定最佳发酵培养基配方,并考察了中间补料方案。经10吨发酵罐连续8批验证,平均发酵效价提高6.11%,产品质量全部合格,原材料消耗成本可降低20%以上。An improved medium formula for erythromycin fermentation by powders A and B to replace starch and/or part of glucose and bean cake was established. The optimization of the medium was carried out by using orthogonal analytical method. The average production level of 8 successive batches in a 10-ton fermentation tank with improved medium was increased by 6. 11% and the raw material cost was reduced by 20% and the products complied with the quality standard requirements.

关 键 词：红霉素 发酵 培养基优化 

分 类 号：R978.15[医药卫生—药品]