诱导HO-1基因表达的信号通路  

Signal transduction pathways of heme oxygenase-1 gene expression

作　　者：杨晓瑜[1] 黄维义[1] 魏宗德[1] 

机构地区：[1]泸州医学院附属医院心内科,四川泸州646000

出　　处：《国际病理科学与临床杂志》2006年第3期238-242,共5页Journal of International Pathology and Clinical Medicine

摘　　要：血红素氧合酶(HO)的诱导型HO-1与其催化血红素降解生成的产物胆红素和CO一道,组成了机体重要的内源性保护系统,广泛参与抗炎与多种急慢性氧化应激损伤。多种理化因素通过不同的细胞内信号转导通路诱导HO-1的表达,这些信号通路涉及丝裂原活化蛋白激酶(MAPKs)、蛋白激酶C(PKC)、cAMP依赖的蛋白激酶A(PKA)、cGMP依赖蛋白激酶G(PKG)、酪氨酸蛋白激酶(TPK)、蛋白磷酸酶(PPs)、磷脂酰肌醇(-3)激酶(PI3K)/Akt。Heme oxygenase-1 （ HO-1 ）, the as well as carbon monoxide, the product of HO-1 d inducible isoform of heme oxygenase, and biliverdin egrading heme, constitute the major endogenous protective system in organism, which widely participates in anti-inflammatory and multiple acute and chronic oxidative stress injury. Many physical and chemical factors induce HO-1 expression by various intracellular signal transduction pathways, such as mitogen-activated protein kinases （ MAPKs）, protein kinase C （PKC）, cAMP-dependentprotein kinase A （PKA）, cGMP-dependent protein kinase G （PKG）, tyrosine protein kinase （ TPK）, protein phosphatase （ PPs）, and phosphatidylinositol 3-kinase （ PI3 K）. There is a significance in preventing and treating diseases that studying and illuminating these pathways reasonably regulates HO-1 expression.

关 键 词：HO-1 信号通路 谷胱甘肽 

分 类 号：R364[医药卫生—病理学]