黄精多糖的生物活性研究  

Biological Activities of Polysaccharides from Polygonatum Sibiricum Redoute

作　　者：张庭廷[1] 夏晓凯[2] 陈传平[1] 吴安平[1] 何梅[1] 聂刘旺[1] 

机构地区：[1]安徽师范大学生命科学学院重点实验室,安徽芜湖241000 [2]湖南省中医药高等专科学校,湖南株洲412012

出　　处：《中国实验方剂学杂志》2006年第7期42-45,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：安徽师范大学"皖泰"应用开发研究项目(2004Wtjj08)

摘　　要：目的:研究黄精多糖(PSP)的生物活性。方法:1.饲料中添加PSP,测定PSP对小鼠血脂的影响;2.测定ig PSP对小鼠的抗衰老作用;3.测定ig PSP对小鼠免疫功能的影响。结果:1.PSP可预防和治疗小鼠高脂血症,降低小鼠血中的胆固醇以及甘油三酯含量;2.PSP可提高7月龄小鼠全血中SOD以及GSH-Px的活性,降低小鼠心、肝、脑组织中LF和MDA含量;3.PSP可提高小鼠腹腔巨噬细胞吞噬百分率和吞噬指数;增加小鼠溶血素的生成;增加正常小鼠DTH反应以及恢复免疫功能低下小鼠的DTH反应。结论:PSP具有降低血脂、延缓小鼠衰老以及增强小鼠免疫功能等作用。Objective： To research the biological activities of polysaccharide from Polygonatum Sibiricum Redoute. Methods： 1. Adding PSP to mouse＇s feed stuff and determining the inhibition of serum lipids by PSP. 2. Feeding mouse with PSP to determine PSP＇s function of anti-aging. 3. Feeding mouse with PSP to determine the immune activities. Results： 1. PSP has obvious effect in preventing from and treatment of mouse hypercholesterolemia. 2. PSP can increase the activities of SOD and GSH-Px in aged mouse blood and decrease the content of LF and MDA in aged mouse heart, liver and brain. 3. PSP has a strong ability to enhance mouse Phagocyte＇ s Phagocytic percentage and Phagocytic index, to increase the content of haemolysin in mouse and the response of the DTH（delayed-type hypersensitivity） in normal mouse and to recover response to DTH in cyclophosphamide（ Cy）intoxicated. Condusion： PSP can reduce the serum lipids, deter aging and enhance the immune reaction in mouse.

关 键 词：黄精多糖 降血脂 抗衰老 免疫功能 

分 类 号：R285.5[医药卫生—中药学]