老年脑梗死患者血浆同型半胱氨酸水平及相关因素研究  

Study of the plasma total homocysteine level and its related factors in gerontal patients suffering from cerebral infarction

作　　者：李永杰[1] 付伟[2] 刘颖[1] 刘菊红[3] 杨铁生[1] 李丰升 高旭光[1] 

机构地区：[1]北京大学人民医院,北京100044 [2]北京京煤集团总医院,北京102300 [3]北京德外医院,北京100011

出　　处：《中华老年心脑血管病杂志》2006年第7期459-461,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：首都医学发展科研基金(2003-3080)

摘　　要：目的分析316例老年脑梗死患者血浆同型半胱氨酸(Hcy)的水平及特点,探讨其相关的因素。方法高效液相色谱检测316例老年脑梗死患者(老年脑梗死组),184例非老年脑梗死患者(非老年脑梗死组)和61例健康老年对照者(健康老年对照组)血浆中Hcy的水平,对老年脑梗死组Hcy的分布特征及相关因素进行统计学分析。结果老年脑梗死组患者血浆Hcy水平(17.91μmol/L)高于健康老年对照组(12.69μmol/L),差异有显著性意义(P<0.001);老年脑梗死组血浆Hcy水平高于非老年脑梗死组(15.72μmol/L),差异无显著性意义(P=0.089);老年脑梗死组患者Hcy水平存在性别差异(t=3.628,P<0.001);Hcy水平与叶酸水平、年龄、性别相关,回归系数分别是-0.137,0.008,-0.086。结论老年脑梗死组患者血浆Hcy水平高于健康老年对照组,男性高于女性,Hcy水平与年龄呈正相关,与叶酸水平呈负相关。Objectives To analyze the fasting plasma total homocysteine （tHcy） level of 316 gerontal patients with cerebral infarction,and investigate the factors influencing tHcy level in these cases.Methods 316 gerontal patients with cerebral infarction, 184 patients younger than 60 years old with cerebral infarction and 61 healthy gerontal controls were recruited. Plasma level of tHcy was assayed by high-performance liquid chromatography （HPLC）.The level of tHcy of gerontal patients and its related factors were analyzed by SPSS 10.0. Results The tHcy level of gerontal patients with cerebral infarction （17.91 μmol/L） was significantly higher （ P 〈 0.001 ） than that of healthy controls （12.69 μmol/L）. Similar results were found between the gerontal patients group and the non-gerontal patients group （15.72 μmol/L）, but the difference had no statistical significance （ P = 0.089）. There was significant difference in the percentage of hyperhomocysteinemia between the three groups （ P 〈 0.001）. In the gerontal patients, there was a significant difference in the levels of tHcy between males and females（ P 〈 0. 001 ）. Result of the stepwise regression analysis showed that the tHcy level of gerontal patients with cerebral infarction correlated with folic acid levels （ r = - 0. 137）, age （ r = 0.008） and gender （ r = -0. 086）. Conclusions The tHcy lcvel of gerontal patients with cerebral infarction was elevated with age, and tHcy level in males was higher than that in females. Elevated Hcy level of gerontal patients with cerebral infarction was significantly associated with the reduction of folic acid.

关 键 词：脑梗塞 半胱氨酸 色谱法 高压液相 因素分析 统计学 

分 类 号：R743.33[医药卫生—神经病学与精神病学]