新型C_2对称的手性双席夫碱的设计合成及结构表征  

Synthesis and characterization of novel C_2 symmetric chiral bidentate Schiff′s base

作　　者：何炜[1] 刘鹏[1] 南鹏娟[1] 金瑛[1] 张生勇[1] 

机构地区：[1]第四军医大学药学系,陕西西安710032

出　　处：《化学试剂》2006年第6期321-322,348,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(20372083);陕西省自然科学基金资助项目(2002B20)

摘　　要：以天然产物奎宁为原料,经亲核取代,还原得到9-氨基奎宁,进而和邻苯二甲醛生成C2对称的手性双席夫碱,总产率达到53%,重要中间体和目标产物的结构经MSI、R1、HNMR和元素分析得到确证。A novel C2 symmetric chiral bidentate Schiff＇ s base was synthesized conveniently from phthalaldehyde and 9-amino （9-deoxy） quinine, which was prepared from natural quinine via nucleophilic substitution and catalytic reduction. The total chemical yield of chiral bidentate Schiff＇ s base was 53 %. The structures of the main intermediates and the aim product were established by MS, IR, ^1HNMR and elemental analysis.

关 键 词：C2对称 手性双席夫碱 合成 

分 类 号：O626.24[理学—有机化学]