VEGF-C在晚期卵巢癌原发灶和转移灶中的表达比较  

Comparison of vascular endothelial growth factor C expression between primary and metastatic sites of ovarian cancer

作　　者：张辉[1] 左连富[2] 王晓玲[3] 王永军[3] 贾金华[1] 康山 赵群[4] 

机构地区：[1]河北医科大学第四医院妇产科,石家庄050011 [2]河北医科大学第四医院肿瘤研究所,石家庄050011 [3]河北医科大学第四医院病理科,石家庄050011 [4]河北医科大学第四医院外科,石家庄050011

出　　处：《免疫学杂志》2006年第4期429-431,共3页Immunological Journal

基　　金：河北省卫生厅科技攻关项目(98028)

摘　　要：目的研究血管内皮生长因子C(VEGFC)在晚期卵巢癌原发灶和转移灶中的表达并进行比较,探讨其与晚期卵巢癌发生、发展及预后的关系。方法应用SP免疫组织化学技术检测52例晚期卵巢癌原发灶以及相应的大网膜转移灶中VEGFC的表达。结果VEGFC在52例卵巢上皮癌中原发灶的高表达率为21%(1152),其中透明细胞癌与黏液性癌相比有显著性差异(χ2=6.97,P<0.01);在转移灶的高表达阳性率为35%(1852),各种组织学类型之间无显著性差异(P>0.01)。卵巢癌原发灶和转移灶之间VEGFC表达无明显差异(P>0.05)。结论VEGFC在晚期卵巢癌组织中表达增高,原发灶与转移灶之间无明显差异。Objective To investigate the expressions of vascular endothelial growth factor C （VEGF-C） in primary and metastatic sites of patients with ovarian cancer. Methods Expressions of VEGF-C in 52 patients with ovarian cancer including primary and metastatic sites were determined by immunohistechemistry. Results The high expression of VEGF-C in primary sites was 21% （ 11 of 52）, among which significant difference of VEGF-C expression was found between mucinous cystadenoma and clear-cell carcinoma （X^2 = 6.97, P 〈 0.01 ）. The high expression of VEGF-C in metastatic sites was 35% （ 18 of 52）, among which no significant difference of VEGF-C expression was found between primary and metastatic sites in patients with ovarian cancer （ P 〉 0.05）. Condusion The VEGF-C expression in metastatic sites may not reflect an aggressive biologic behavior in ovarian cancer.

关 键 词：卵巢癌 血管内皮生长因子C 原发灶 转移灶 预后 

分 类 号：R737.31[医药卫生—肿瘤]