Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin ll-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts  

作　　者：WANG Xiao-dan CHEN Xiang-mei WANG Jian-zhong HONG Quan FENG Zhe FU Bo ZHOU Feng WANG Feng-yang FAN Dai-ming 

机构地区：[1]Department of Nephrology, General Hospital of People＇s Liberation Army, Beijing 100853, China [2]Department of Gastroenterology, Fourth Military Medical University, Xi＇an 710032, China [3]Institute of Genome Research, Tsinghua University, Beijing 100084, China

出　　处：《Chinese Medical Journal》2006年第13期1094-1102,共9页中华医学杂志（英文版）

基　　金：This work was supported by grants from the Creative Research Group Fund of the Natural Science Foundation of China (No.30121005) the National Science Foundation of China (No.30370559) the Medical Health Research Fund of People's Liberation Army of China (No. 04T6003) the Major Basic Project of China (973) (No.G2000057000).

摘　　要：Backgroud Angiotensin Ⅱ （Ang Ⅱ）, a principal effector of renin-angiotensin system （RAS） and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ （AT1） and induce nuclear translocation of signal transducers and activators of transcription （STAT）. To further explore the role of Ang Ⅱ in aging, we examined the effect of Ang Ⅱ on human replicative senescent diploid fibroblast WI-38 cells.Backgroud Angiotensin Ⅱ （Ang Ⅱ）, a principal effector of renin-angiotensin system （RAS） and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ （AT1） and induce nuclear translocation of signal transducers and activators of transcription （STAT）. To further explore the role of Ang Ⅱ in aging, we examined the effect of Ang Ⅱ on human replicative senescent diploid fibroblast WI-38 cells.

关 键 词：STAT3 protein  human tissue inhibitor of metalloproteinase-1 angiotensin Ⅱ aging FIBROBLASTS 

分 类 号：Q51[生物学—生物化学]