三亚地区翼状胬肉发病与紫外线暴露时间相关关系研究  

Relationship between pterygium onset and ultraviolet rays exposure time

作　　者：阎启昌[1] 刘忠鑫 邸悦[1] 王尉[1] 高倩[3] 张劲松[1] 刘扬[3] 刘嵘[4] 

机构地区：[1]中国医科大学附属第四医院眼科,沈阳110005 [2]三亚市人民医院眼科 [3]中国医科大学公共卫生学院环境卫生教研室 [4]中国医科大学公共卫生统计教研室

出　　处：《中华医学杂志》2006年第24期1686-1688,共3页National Medical Journal of China

基　　金：国家自然科学基金资助项目(40275036);辽宁省教育厅高等学校科学研究项目(2004C026)

摘　　要：目的研究紫外线辐射与翼状胬肉发病的量效关系。方法海南省三亚市崖城地区95例翼状胬肉患者作为翼状胬肉组,在当地人群中按相同年龄、性别、民族、是否戴眼镜和帽子的标准选取95名志愿者进行1∶1配对,作为正常对照。将两组人群按年龄分为青年、中年、老年3个阶段,通过详细询问研究对象个体累积户外活动的时间,填写调查表,以此计算个体紫外线暴露时间,作为紫外线暴露量,进行比较分析两组的紫外线暴露时间与翼状胬肉发病的关系。结果在青年组(35 637 h+13 587 h or 26 188 h+17 423 h;t=3.352,P=0.006,与中年组(73 412 h+23 082 h or 63368 h+25 091 h;t=2.322,P=0.024)患有翼状胬肉人群紫外线暴露时间明显高于对照组,而在老年翼状胬肉组(106 816 h+37 423 h or 106 748 h+43 111 h)与对照组的紫外线暴露时间未见有统计学意义(t=0.008,P=0.994);翼状胬肉的长度与紫外线暴露时间呈正相关(r=0.361,P<0.05),且随年龄增长而其长度也增加。结论紫外线辐射与翼状胬肉发病之间存在一定的量效关系。Objective To investigate the dose-effect relationship between the radiation of ultraviolet ray and the onset of pterygium quantitatively. Methods Interrogation was conducted to 95 patients with pterygium in Yacheng district, Sanya City, Hainan Province, 37 males and 58 females, aged 55.7 ± 13.8 （20 - 80）, and 95 local volunteers in 1：1 pairs matched in age, sex, race, and similar habits of wearing glasses and caps （control group）. Both the pterygium group and control group were re-divided into three sub-groups： youth （ aged ≤ 40）, middle-aged （ aged 41 - 60）, and elderly （ aged 〉 60）. The time of exposing to ultraviolet ray was calculated. Photo of the pterygium was taken. The length of the pterygium invading into cornea was measured. Results The ultraviolet ray exposure time of the youth subgroup, pterygium group, was 35637 ± 13587 hours, significantly higher than that of the youth subgroup, control group （26 188 ± 17 423 hours, t = 3. 352, P = 0.006）. The ultraviolet ray exposure time of the middle-aged subgroup, pterygium group, was 73 412 ± 23 082 hours, significantly higher than that of the middle-aged subgroup, control group （63 368 ±25 091 hours, t =2.322 ,P =0.024）. However, there was no significant difference in the ultraviolet ray exposure time between the elderly subgroups of both groups. The length of the pterygium invading into cornea was positively correlated with the ultraviolet ray exposure time （ r = 0. 361, P 〈 0.05）, and the length showed a trend of increased with aging. Condusion There is a certain doseeffect correlation between ultraviolet ray exposure and the etiology of pteryglum.

关 键 词：翼状胬肉 紫外线 暴露时间 

分 类 号：R777.33[医药卫生—眼科]