p^（53）蛋白的过度表达与胃肠道平滑肌肉瘤的预后  

THE EXPRESSION OF p￣(53) PROTEIN IN LEIOMYOSARCOMA OF THE DIGESTIVE TRACT AND ITS CORRELATION TO GRADE AND PROGNOSIS

作　　者：汪筱娟[1,2] 唐卫华[1,2] 李利 于佩良 刘文君[1,2] 谭燕泉 

机构地区：[1]山东医科大学病理解剖学教研室 [2]曹县人民医院

出　　处：《山东医科大学学报》1996年第4期287-290,共4页Acta Academiae Medicinae Shandong

摘　　要：应用免疫组织化学方法（ＬＳＡＢ）法，检测５１例胃肠道平滑肌肉瘤（ＡＬＳ）中ｐ５３基因蛋白产物的表达情况，探讨ｐ５３蛋白的表达与ＡＬＳ组织学分级、预后相关因素的关系。结果显示，ＡＬＳ中ｐ５３蛋白阳性率为４４％；ｐ５３蛋白在组织学Ⅱ～Ⅲ级中的阳性率明显高于Ⅰ级（Ｐ＜０．０５），死亡组ｐ５３的阳性率高于生存组（Ｐ＜０．０５）。表明ｐ５３蛋白基因突变与胃肠道平滑肌肉瘤的发生、发展有关，ｐ５３蛋白可做为临床估计ＡＬＳ预后的客观参考指标。The expression of p￣(53) protein in alimentery leiomyosarcoma(ALS) and its correlation to grade and prognosis were studied in 5l cases by immunohistochemical technique. 44% cases stained positive for p￣(53) protein. There was a significant difference in the rate of the survival group and death group(P<0. 05). The positive rate of grade Ⅱand Ⅲ was also significantly differ from grade I (P<0. 05). The results suggest that p￣(53)protein status can be used as an indicator of the grade and prognosis of ALS.

关 键 词：胃肠肿瘤 平滑肌肉瘤 P^53蛋白 免疫组织化学 

分 类 号：R735.07[医药卫生—肿瘤] R730.3[医药卫生—临床医学]