CaMKⅣ在子宫内膜癌细胞中表达的研究  

Study of CaMKⅣ expression in endometrial carcinoma

作　　者：商素洁[1] 庞义存[1] 杜建层[1] 

机构地区：[1]河北医科大学第三医院妇产科,050051

出　　处：《中国妇幼保健》2006年第13期1837-1839,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨CaMKⅣ在子宫内膜癌发病中的作用。方法:采用免疫组化方法,检测31例子宫内膜癌患者和20例正常子宫内膜标本中CaMKIV的表达强度,同时分析CaMKⅣ染色细胞的百分数与患者临床特征的关系(临床分期、组织分级和临床预后)。结果:正常子宫内膜组织细胞无CaMKⅣ的表达,CaMKⅣ表达主要在子宫内膜癌细胞核内,表达的强弱与临床分期和预后有关。结论:CaMKⅣ在子宫内膜癌组织中的表达与子宫内膜癌的恶性程度有关。Objective： To study the involvement of CaMKIV in endometrial carcinogenesis. Methods： CaMKIV protein expression from 31 patients with endometrial carcinoma and 20 patients normal endometria were detected by immunohistochemistry to analyze the relationship between the percentages of CaMKIV stained cells and the patient characteristics, such as clinical stage, histological grade, and clinical outcome. Results： In the normal endometrial , CaMKIV was detected in none of the cases examined. Most of the CaMKIV proteins were found in the nucleus of endometrial carcinoma tissue. CaMKIV expression was significantly associated with clinical stage （ stage Ⅰ and Ⅱ versus stage Ⅲ and Ⅳ, P 〈 0. 01 ） , and clinical outcome. Conclusion： CaMKIVexpression in endometrial carcinoma correlates with the malignant potential of this tumor.

关 键 词：子宫内膜癌CaMKⅣ 免疫组织化学 

分 类 号：R737.3[医药卫生—肿瘤]